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- W1996140740 endingPage "1166" @default.
- W1996140740 startingPage "1139" @default.
- W1996140740 abstract "m-Chlorophenylpiperazine (mCPP) is the most extensively used probe of serotonin function in psychiatry. This article reviews its in vitro and in vivo properties in animals, normal human subjects, and psychiatric patients. mCPP is a safe, reliable, direct 5-hydroxytryptamine (5HT) agonist, which may be used to evaluate 5HT receptor sensitivity. It causes a consistent, dose-dependent elevation of ACTH, cortisol, and prolactin levels in both animals and humans, as well as increased body temperature in man. It also causes a variety of behavioral effects, depending on the population studied. These effects are probably 5HT receptor-related, although specific 5HT receptor subtype mechanisms have not yet been established. mCPP may be considered an important addition to armamentarium of 5HT receptor probes, which is especially useful until more selective 5HT receptor agonists have been tested." @default.
- W1996140740 created "2016-06-24" @default.
- W1996140740 creator A5031613969 @default.
- W1996140740 creator A5062786102 @default.
- W1996140740 date "1991-12-01" @default.
- W1996140740 modified "2023-10-16" @default.
- W1996140740 title "m-Chlorophenylpiperazine as a probe of serotonin function" @default.
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- W1996140740 doi "https://doi.org/10.1016/0006-3223(91)90184-n" @default.
- W1996140740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1663792" @default.