FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996154237> ?p ?o ?g. }

• W1996154237 endingPage "110" @default.
• W1996154237 startingPage "101" @default.
• W1996154237 abstract "While most approaches to repair spinal cord injury (SCI) rely on promoting axon outgrowth, the extensive distance that axons would have to grow to bridge SCI lesions remains an enormous challenge. In this study, we used a new tissue-engineering technique to create long nervous tissue constructs spanned by living axon tracts to repair long SCI lesions. Exploiting the newfound process of extreme axon stretch growth, integrated axon tracts from dorsal root ganglia (DRG) neurons were mechanically elongated in vitro to 10 mm over 7 days and encased in a collagen hydrogel to form a nervous tissue construct. In addition, a modified lateral hemisection SCI model in the rat was developed to create a 1 cm long cavity in the spinal cord. Ten days following SCI, constructs were transplanted into the lesion and the animals were euthanized 4 weeks post-transplantation for histological analyses. Through cell tracking methods and immunohistochemistry, the transplanted elongated cultures were consistently found to survive 4 weeks in the injured spinal cord. In addition, DRG axons were observed extending out of the transplanted construct into the host spinal cord tissue. These results demonstrate the promise of nervous tissue constructs consisting of stretch-grown axons to bridge even extensive spinal cord lesions." @default.
• W1996154237 created "2016-06-24" @default.
• W1996154237 creator A5011010380 @default.
• W1996154237 creator A5025276777 @default.
• W1996154237 creator A5028906571 @default.
• W1996154237 creator A5036156431 @default.
• W1996154237 creator A5090108208 @default.
• W1996154237 date "2006-01-01" @default.
• W1996154237 modified "2023-10-14" @default.
• W1996154237 title "Long-Term Survival and Outgrowth of Mechanically Engineered Nervous Tissue Constructs Implanted Into Spinal Cord Lesions" @default.
• W1996154237 cites W1566509581 @default.
• W1996154237 cites W1574222606 @default.
• W1996154237 cites W1952053031 @default.
• W1996154237 cites W1964930634 @default.
• W1996154237 cites W1966567222 @default.
• W1996154237 cites W1971219758 @default.
• W1996154237 cites W1973273107 @default.
• W1996154237 cites W1980713523 @default.
• W1996154237 cites W1984133636 @default.
• W1996154237 cites W1990194853 @default.
• W1996154237 cites W1999048005 @default.
• W1996154237 cites W2009571615 @default.
• W1996154237 cites W2013700695 @default.
• W1996154237 cites W2024698716 @default.
• W1996154237 cites W2026508268 @default.
• W1996154237 cites W2037706507 @default.
• W1996154237 cites W2049393475 @default.
• W1996154237 cites W2073861900 @default.
• W1996154237 cites W2076492394 @default.
• W1996154237 cites W2078457604 @default.
• W1996154237 cites W2081841141 @default.
• W1996154237 cites W2089382097 @default.
• W1996154237 cites W2089776797 @default.
• W1996154237 cites W2091404665 @default.
• W1996154237 cites W2096988407 @default.
• W1996154237 cites W2101996466 @default.
• W1996154237 cites W2113724937 @default.
• W1996154237 cites W2123450039 @default.
• W1996154237 cites W2128955603 @default.
• W1996154237 cites W2152531207 @default.
• W1996154237 cites W2161475511 @default.
• W1996154237 cites W2171508801 @default.
• W1996154237 cites W4252738189 @default.
• W1996154237 doi "https://doi.org/10.1089/ten.2006.12.101" @default.
• W1996154237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16499447" @default.
• W1996154237 hasPublicationYear "2006" @default.
• W1996154237 type Work @default.
• W1996154237 sameAs 1996154237 @default.
• W1996154237 citedByCount "58" @default.
• W1996154237 countsByYear W19961542372012 @default.
• W1996154237 countsByYear W19961542372013 @default.
• W1996154237 countsByYear W19961542372014 @default.
• W1996154237 countsByYear W19961542372015 @default.
• W1996154237 countsByYear W19961542372016 @default.
• W1996154237 countsByYear W19961542372017 @default.
• W1996154237 countsByYear W19961542372018 @default.
• W1996154237 countsByYear W19961542372019 @default.
• W1996154237 countsByYear W19961542372020 @default.
• W1996154237 countsByYear W19961542372021 @default.
• W1996154237 countsByYear W19961542372022 @default.
• W1996154237 crossrefType "journal-article" @default.
• W1996154237 hasAuthorship W1996154237A5011010380 @default.
• W1996154237 hasAuthorship W1996154237A5025276777 @default.
• W1996154237 hasAuthorship W1996154237A5028906571 @default.
• W1996154237 hasAuthorship W1996154237A5036156431 @default.
• W1996154237 hasAuthorship W1996154237A5090108208 @default.
• W1996154237 hasConcept C100776233 @default.
• W1996154237 hasConcept C105702510 @default.
• W1996154237 hasConcept C136229726 @default.
• W1996154237 hasConcept C141071460 @default.
• W1996154237 hasConcept C142724271 @default.
• W1996154237 hasConcept C169760540 @default.
• W1996154237 hasConcept C2777921445 @default.
• W1996154237 hasConcept C2778334475 @default.
• W1996154237 hasConcept C2779530196 @default.
• W1996154237 hasConcept C2780775167 @default.
• W1996154237 hasConcept C2911091166 @default.
• W1996154237 hasConcept C49892992 @default.
• W1996154237 hasConcept C529278444 @default.
• W1996154237 hasConcept C545706735 @default.
• W1996154237 hasConcept C71924100 @default.
• W1996154237 hasConcept C86803240 @default.
• W1996154237 hasConceptScore W1996154237C100776233 @default.
• W1996154237 hasConceptScore W1996154237C105702510 @default.
• W1996154237 hasConceptScore W1996154237C136229726 @default.
• W1996154237 hasConceptScore W1996154237C141071460 @default.
• W1996154237 hasConceptScore W1996154237C142724271 @default.
• W1996154237 hasConceptScore W1996154237C169760540 @default.
• W1996154237 hasConceptScore W1996154237C2777921445 @default.
• W1996154237 hasConceptScore W1996154237C2778334475 @default.
• W1996154237 hasConceptScore W1996154237C2779530196 @default.
• W1996154237 hasConceptScore W1996154237C2780775167 @default.
• W1996154237 hasConceptScore W1996154237C2911091166 @default.
• W1996154237 hasConceptScore W1996154237C49892992 @default.
• W1996154237 hasConceptScore W1996154237C529278444 @default.
• W1996154237 hasConceptScore W1996154237C545706735 @default.
• W1996154237 hasConceptScore W1996154237C71924100 @default.
• W1996154237 hasConceptScore W1996154237C86803240 @default.

• next