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- W1996160886 abstract "Arginine vasopressin (AVP) release was studied in 16 chronic fetal preparations between 101 and 141 days gestation following the infusion of 5% NaCl. The mean baseline plasma AVP in fetuses from 101-120 (N=20) days was 1.90 ± 0.46 μU/ml with a plasma osmolality of 292.9 ± 1.75 mOsm/kg. In fetuses 121 days to 141 days gestation, the mean baseline plasma AVP (N=11) was significantly lower 0.77 ± 0.19 μU/ml (P=<0.05) whereas the plasma osmolality was similar to that in the younger fetuses (292.7 ± 1.9 mOsm/kg). The paired maternal baseline AVP concentrations at 101 and 120 days gestation were significantly lower (0.843 ± 0.17 μU/ml) than the mean fetal levels (1.59 ± 0.44 μU/ml) however fetal and maternal levels between 121-141 days were similar; 0.68 ± 0.27 μU/ml and 0.70 ± 0.22 μU/ml respectively. A linear regression of the logarithum of baseline plasma AVP and plasma osmolality in 30 fetuses showed a significant correlation (P=<0.001, r=0.62). Plasma AVP was elevated after 5% NaCl infusion in 16 of 19 experiments. Studies of the relationship between steady state plasma AVP and plasma osmolality in adult sheep show a slightly flatter slope (adult 0.0282, fetal 0.0395). This observation suggests that the fetal osmoreceptors are more responsive to changes in tonicity than the adult sheep. Furthermore, the response to 5% NaCl as measured by the difference in the log plasma AVP divided by the difference in plasma osmolality was greater in the fetus." @default.
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- W1996160886 date "1977-04-01" @default.
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- W1996160886 title "VASOPRESSIN RELEASE IN THE LAMB FETUS" @default.
- W1996160886 doi "https://doi.org/10.1203/00006450-197704000-00255" @default.
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