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- W1996161844 abstract "Background: Nonalcoholic steatohepatitis (NASH) is the hepatic manifestation of obesity and can progress to liver cirrhosis even during childhood and early adulthood. The aim of this study was to determine the frequency of NASH as an indication for liver transplantation (LT) in children and young adults and to characterize patient and graft survival in this cohort using a comprehensive large national liver transplantation registry in the U.S. Methods: The study included all children and young adult patients (up to the age of 40 years) who underwent LT in the U.S. from the 1987-2012 United Network for Organ Sharing and Organ Procurement and Transplantation Network (UNOS/OPTN) database. We created a modified NASH category that included LT recipients who were given a primary diagnosis of NASH plus obese patients with primary diagnosis of cryptogenic cirrhosis (CC). KaplanMeier analysis was used to assess patient and graft survival. Results: A total of 330 patients were included (111 with NASH and 219 with CC and BMI ≥ 30 kg/m2). 52% were male, 68% were Caucasian, the mean BMI was 33.6 ± 6.3 and diabetes was present in 18%. Age at time of LT ranged between 4 and 40 years with a mean of 33.9 ± 6.6 years. 14 subjects were < 18 years of age at time of LT and 20 were between the ages of 18-25 years. A progressive increase in NASH as the primary indication for LT in young subjects is seen from 2001 to 2012 (Figure). Median follow-up after 1st LT was 45.8 months [10.7, 97.3]. During this time 30% of subjects (n = 100) died and 11.5% (n = 38) were re-transplanted including 13 for NASH recurrence. Conclusion: NASH can progress to end-stage liver disease requiring LT in childhood and early adulthood. A significant number of young patients transplanted for NASH cirrhosis required re-transplantation with one third being done for NASH recurrence." @default.
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- W1996161844 date "2015-04-01" @default.
- W1996161844 modified "2023-10-16" @default.
- W1996161844 title "Su1039 The Longitudinal Association Between Alcohol Consumption and Fatty Liver in Japanese Subjects" @default.
- W1996161844 doi "https://doi.org/10.1016/s0016-5085(15)33569-1" @default.
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