Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996163048> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1996163048 abstract "The accuracy of genetic network inference is limited by the assumptions used to determine if one hypothetical model is better than another in explaining experimental observations. Most previous work on epistasis analysis—in which one attempts to infer pathway relationships by determining equivalences among traits following mutations—has been based on Boolean or linear models. Here, we delineate the ultimate limits of epistasis-based inference by systematically surveying all two-gene network motifs and use symbolic algebra with arbitrary regulation functions to examine trait equivalences. Our analysis divides the motifs into equivalence classes, where different genetic perturbations result in indistinguishable experimental outcomes. We demonstrate that this partitioning can reveal important information about network architecture, and show, using simulated data, that it greatly improves the accuracy of genetic network inference methods. Because of the minimal assumptions involved, equivalence partitioning has broad applicability for gene network inference." @default.
- W1996163048 created "2016-06-24" @default.
- W1996163048 creator A5009680404 @default.
- W1996163048 creator A5026871523 @default.
- W1996163048 creator A5057807980 @default.
- W1996163048 date "2013-06-01" @default.
- W1996163048 modified "2023-09-26" @default.
- W1996163048 title "Identifiability and inference of pathway motifs by epistasis analysis" @default.
- W1996163048 cites W1967220526 @default.
- W1996163048 cites W1969154599 @default.
- W1996163048 cites W1974317514 @default.
- W1996163048 cites W1988263223 @default.
- W1996163048 cites W2007769474 @default.
- W1996163048 cites W2023348596 @default.
- W1996163048 cites W2033637309 @default.
- W1996163048 cites W2084377907 @default.
- W1996163048 cites W2094189284 @default.
- W1996163048 cites W2094683075 @default.
- W1996163048 cites W2117033519 @default.
- W1996163048 cites W2129558874 @default.
- W1996163048 cites W2130139983 @default.
- W1996163048 cites W2133102806 @default.
- W1996163048 cites W2134759932 @default.
- W1996163048 cites W2139997707 @default.
- W1996163048 cites W2147566730 @default.
- W1996163048 cites W2150749732 @default.
- W1996163048 cites W2153134824 @default.
- W1996163048 cites W2361838659 @default.
- W1996163048 doi "https://doi.org/10.1063/1.4807483" @default.
- W1996163048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23822501" @default.
- W1996163048 hasPublicationYear "2013" @default.
- W1996163048 type Work @default.
- W1996163048 sameAs 1996163048 @default.
- W1996163048 citedByCount "8" @default.
- W1996163048 countsByYear W19961630482013 @default.
- W1996163048 countsByYear W19961630482014 @default.
- W1996163048 countsByYear W19961630482015 @default.
- W1996163048 countsByYear W19961630482017 @default.
- W1996163048 countsByYear W19961630482018 @default.
- W1996163048 crossrefType "journal-article" @default.
- W1996163048 hasAuthorship W1996163048A5009680404 @default.
- W1996163048 hasAuthorship W1996163048A5026871523 @default.
- W1996163048 hasAuthorship W1996163048A5057807980 @default.
- W1996163048 hasConcept C104317684 @default.
- W1996163048 hasConcept C118615104 @default.
- W1996163048 hasConcept C119857082 @default.
- W1996163048 hasConcept C122770356 @default.
- W1996163048 hasConcept C150194340 @default.
- W1996163048 hasConcept C154945302 @default.
- W1996163048 hasConcept C2776214188 @default.
- W1996163048 hasConcept C2780069185 @default.
- W1996163048 hasConcept C2986044853 @default.
- W1996163048 hasConcept C2991772755 @default.
- W1996163048 hasConcept C33923547 @default.
- W1996163048 hasConcept C41008148 @default.
- W1996163048 hasConcept C54355233 @default.
- W1996163048 hasConcept C61727976 @default.
- W1996163048 hasConcept C67339327 @default.
- W1996163048 hasConcept C70721500 @default.
- W1996163048 hasConcept C80444323 @default.
- W1996163048 hasConcept C86803240 @default.
- W1996163048 hasConceptScore W1996163048C104317684 @default.
- W1996163048 hasConceptScore W1996163048C118615104 @default.
- W1996163048 hasConceptScore W1996163048C119857082 @default.
- W1996163048 hasConceptScore W1996163048C122770356 @default.
- W1996163048 hasConceptScore W1996163048C150194340 @default.
- W1996163048 hasConceptScore W1996163048C154945302 @default.
- W1996163048 hasConceptScore W1996163048C2776214188 @default.
- W1996163048 hasConceptScore W1996163048C2780069185 @default.
- W1996163048 hasConceptScore W1996163048C2986044853 @default.
- W1996163048 hasConceptScore W1996163048C2991772755 @default.
- W1996163048 hasConceptScore W1996163048C33923547 @default.
- W1996163048 hasConceptScore W1996163048C41008148 @default.
- W1996163048 hasConceptScore W1996163048C54355233 @default.
- W1996163048 hasConceptScore W1996163048C61727976 @default.
- W1996163048 hasConceptScore W1996163048C67339327 @default.
- W1996163048 hasConceptScore W1996163048C70721500 @default.
- W1996163048 hasConceptScore W1996163048C80444323 @default.
- W1996163048 hasConceptScore W1996163048C86803240 @default.
- W1996163048 hasIssue "2" @default.
- W1996163048 hasLocation W19961630481 @default.
- W1996163048 hasLocation W19961630482 @default.
- W1996163048 hasOpenAccess W1996163048 @default.
- W1996163048 hasPrimaryLocation W19961630481 @default.
- W1996163048 hasRelatedWork W1996163048 @default.
- W1996163048 hasRelatedWork W2101593655 @default.
- W1996163048 hasRelatedWork W2103524869 @default.
- W1996163048 hasRelatedWork W2128506325 @default.
- W1996163048 hasRelatedWork W2540716273 @default.
- W1996163048 hasRelatedWork W2936979086 @default.
- W1996163048 hasRelatedWork W2954218722 @default.
- W1996163048 hasRelatedWork W2963058055 @default.
- W1996163048 hasRelatedWork W3014452852 @default.
- W1996163048 hasRelatedWork W3159699835 @default.
- W1996163048 hasVolume "23" @default.
- W1996163048 isParatext "false" @default.
- W1996163048 isRetracted "false" @default.
- W1996163048 magId "1996163048" @default.
- W1996163048 workType "article" @default.