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• W1996173637 endingPage "1676" @default.
• W1996173637 startingPage "1666" @default.
• W1996173637 abstract "Metyrapone blocks cortisol synthesis, which results in the stimulation of hypothalamic cortiocotropin-releasing factor (CRF) and a reduction in delta sleep. We examined the effect of metyrapone administration on endocrine and sleep measures in male subjects with and without chronic PTSD. We hypothesized that metyrapone would result in a decrease in delta sleep and that the magnitude of this decrease would be correlated with the endocrine response. Finally, we utilized the delta sleep response to metyrapone as an indirect measure of hypothalamic CRF activity and hypothesized that PTSD subjects would have decreased delta sleep at baseline and a greater decrease in delta sleep induced by metyrapone. Three nights of polysomnography were obtained in 24 male subjects with combat-related PTSD and 18 male combat-exposed normal controls. On day 3, metyrapone was administered during normal waking hours until habitual sleep onset preceding night 3. Endocrine responses to metyrapone were measured in plasma obtained the morning following sleep recordings, the day before and after administration. Repeated measures ANOVAs were conducted to compare the endocrine and sleep response to metyrapone in PTSD and controls. PTSD subjects had significantly less delta sleep as indexed by stages 3 and 4, and total delta integrated amplitude prior to metyrapone administration. There were no differences in premetyrapone cortisol or ACTH levels in PTSD vs controls. PTSD subjects had a significantly decreased ACTH response to metyrapone compared to controls. Metyrapone caused an increase in awakenings and a marked decrease in quantitative measures of delta sleep that was significantly greater in controls compared to PTSD. The decline in delta sleep was significantly associated with the magnitude of increase in both 11-deoxycortisol and ACTH. The results suggest that the delta sleep response to metyrapone is a measure of the brain response to increases in hypothalamic CRF. These data also suggest that the ACTH and sleep EEG response to hypothalamic CRF is decreased in PTSD." @default.
• W1996173637 created "2016-06-24" @default.
• W1996173637 creator A5004377511 @default.
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• W1996173637 date "2003-04-22" @default.
• W1996173637 modified "2023-10-12" @default.
• W1996173637 title "Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder" @default.
• W1996173637 cites W124488089 @default.
• W1996173637 cites W141444043 @default.
• W1996173637 cites W1733837299 @default.
• W1996173637 cites W1746209842 @default.
• W1996173637 cites W1886580089 @default.
• W1996173637 cites W1925042390 @default.
• W1996173637 cites W1964204853 @default.
• W1996173637 cites W1965376635 @default.
• W1996173637 cites W1966460145 @default.
• W1996173637 cites W1970468270 @default.
• W1996173637 cites W1972290580 @default.
• W1996173637 cites W1974077278 @default.
• W1996173637 cites W1974157146 @default.
• W1996173637 cites W1974301869 @default.
• W1996173637 cites W1974621684 @default.
• W1996173637 cites W1975302778 @default.
• W1996173637 cites W1976699621 @default.
• W1996173637 cites W1976735983 @default.
• W1996173637 cites W1980615352 @default.
• W1996173637 cites W1982045506 @default.
• W1996173637 cites W1984776877 @default.
• W1996173637 cites W1985647494 @default.
• W1996173637 cites W1986182757 @default.
• W1996173637 cites W1986944693 @default.
• W1996173637 cites W1991232931 @default.
• W1996173637 cites W1994576640 @default.
• W1996173637 cites W1995222718 @default.
• W1996173637 cites W1995752472 @default.
• W1996173637 cites W1996199714 @default.
• W1996173637 cites W1999852904 @default.
• W1996173637 cites W2002341777 @default.
• W1996173637 cites W2003393473 @default.
• W1996173637 cites W2006304441 @default.
• W1996173637 cites W2007135601 @default.
• W1996173637 cites W2007848947 @default.
• W1996173637 cites W2009637266 @default.
• W1996173637 cites W2011943672 @default.
• W1996173637 cites W2013810547 @default.
• W1996173637 cites W2013935018 @default.
• W1996173637 cites W2014416076 @default.
• W1996173637 cites W2015219993 @default.
• W1996173637 cites W2017645883 @default.
• W1996173637 cites W2018222414 @default.
• W1996173637 cites W2018622017 @default.
• W1996173637 cites W2021987746 @default.
• W1996173637 cites W2024416743 @default.
• W1996173637 cites W2026156430 @default.
• W1996173637 cites W2027169786 @default.
• W1996173637 cites W2027593853 @default.
• W1996173637 cites W2028056159 @default.
• W1996173637 cites W2035490031 @default.
• W1996173637 cites W2039546583 @default.
• W1996173637 cites W2040727780 @default.
• W1996173637 cites W2045629189 @default.
• W1996173637 cites W2046272706 @default.
• W1996173637 cites W2046738743 @default.
• W1996173637 cites W2050061211 @default.
• W1996173637 cites W2058121737 @default.
• W1996173637 cites W2060023852 @default.
• W1996173637 cites W2062128247 @default.
• W1996173637 cites W2063403260 @default.
• W1996173637 cites W2063929623 @default.
• W1996173637 cites W2067221643 @default.
• W1996173637 cites W2067495470 @default.
• W1996173637 cites W2069336217 @default.
• W1996173637 cites W2071057820 @default.
• W1996173637 cites W2071937025 @default.
• W1996173637 cites W2079856030 @default.
• W1996173637 cites W2083517874 @default.
• W1996173637 cites W2086405833 @default.
• W1996173637 cites W2087224713 @default.
• W1996173637 cites W2090009913 @default.
• W1996173637 cites W2090358044 @default.
• W1996173637 cites W2091637158 @default.
• W1996173637 cites W2094286961 @default.
• W1996173637 cites W2102086493 @default.
• W1996173637 cites W2102788189 @default.
• W1996173637 cites W2105194498 @default.
• W1996173637 cites W2108367092 @default.
• W1996173637 cites W2127903745 @default.
• W1996173637 cites W2134199290 @default.
• W1996173637 cites W2155255460 @default.
• W1996173637 cites W2166334704 @default.
• W1996173637 cites W2340023437 @default.

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