FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996177248> ?p ?o ?g. }

• W1996177248 endingPage "444" @default.
• W1996177248 startingPage "438" @default.
• W1996177248 abstract "Background We recently found that peripheral administration of the quaternary lidocaine derivative, QX-314, produces long-lasting sensory and motor blockade in animals. The goal of this study was to test whether intrathecal QX-314 has similar properties. Methods We conducted a randomized, double-controlled, blinded study with female CD-1 mice. Animals in the treatment group received lumbar intrathecal QX-314 (0.5-10 mM; volume, 2 microl; each concentration, n = 6). Normal saline and lidocaine (70 mM) served as negative and positive controls (each group, n = 12), respectively. Animals were tested for up to 3 h for lumbosacral neural blockade and observed for adverse effects. Results No animal injected with saline and 11 of 12 (92%) animals injected with lidocaine displayed reversible lumbosacral motor blockade (P &lt; 0.001). QX-314 (5 mM) produced motor blockade in four of the six (67%) and sensory blockade in five of the six animals (83%; P &lt; 0.05 vs. saline). However, six of the six mice (100%) at 5 mM QX-314 and five of the six (83%) at 10 mM exhibited marked irritation; one of the six animals at 5 mM (17%) and two of the six at 10 mM (33%) died. We observed no neural blockade without adverse effects in any animal injected with QX-314. All animals injected with saline and 11 of the 12 (92%) animals injected with lidocaine demonstrated normal behavior. Conclusion Lumbar intrathecal QX-314 concentration-dependently produced irritation and death in mice, at lower concentrations than those associated with robust motor blockade. Although QX-314 did produce long-lasting neural blockade, these findings indicate that QX-314 is unlikely to be a suitable candidate for spinal anesthesia in humans." @default.
• W1996177248 created "2016-06-24" @default.
• W1996177248 creator A5023017451 @default.
• W1996177248 creator A5025664510 @default.
• W1996177248 creator A5034752865 @default.
• W1996177248 creator A5053636583 @default.
• W1996177248 creator A5076741407 @default.
• W1996177248 creator A5087861405 @default.
• W1996177248 date "2010-08-01" @default.
• W1996177248 modified "2023-09-23" @default.
• W1996177248 title "Lumbar Intrathecal Administration of the Quaternary Lidocaine Derivative, QX-314, Produces Irritation and Death in Mice" @default.
• W1996177248 cites W1582039785 @default.
• W1996177248 cites W1934888587 @default.
• W1996177248 cites W1959590443 @default.
• W1996177248 cites W1966371053 @default.
• W1996177248 cites W1968217697 @default.
• W1996177248 cites W1972074413 @default.
• W1996177248 cites W1977652250 @default.
• W1996177248 cites W1986249800 @default.
• W1996177248 cites W1986902257 @default.
• W1996177248 cites W1988899007 @default.
• W1996177248 cites W1989857300 @default.
• W1996177248 cites W1993919474 @default.
• W1996177248 cites W1994663926 @default.
• W1996177248 cites W2000200981 @default.
• W1996177248 cites W2001990910 @default.
• W1996177248 cites W2019208599 @default.
• W1996177248 cites W2022846137 @default.
• W1996177248 cites W2024012135 @default.
• W1996177248 cites W2027137598 @default.
• W1996177248 cites W2028434053 @default.
• W1996177248 cites W2030214947 @default.
• W1996177248 cites W2031003150 @default.
• W1996177248 cites W2034102455 @default.
• W1996177248 cites W2037617419 @default.
• W1996177248 cites W2047803932 @default.
• W1996177248 cites W2052194038 @default.
• W1996177248 cites W2058672163 @default.
• W1996177248 cites W2058700471 @default.
• W1996177248 cites W2063084752 @default.
• W1996177248 cites W2064978976 @default.
• W1996177248 cites W2065869680 @default.
• W1996177248 cites W2069477294 @default.
• W1996177248 cites W2070233250 @default.
• W1996177248 cites W2073265098 @default.
• W1996177248 cites W2073474277 @default.
• W1996177248 cites W2075749787 @default.
• W1996177248 cites W2076558372 @default.
• W1996177248 cites W2080387083 @default.
• W1996177248 cites W2090823918 @default.
• W1996177248 cites W2110729667 @default.
• W1996177248 cites W2114605607 @default.
• W1996177248 cites W2122787296 @default.
• W1996177248 cites W2142828467 @default.
• W1996177248 cites W2150572794 @default.
• W1996177248 cites W2168210103 @default.
• W1996177248 cites W2406947255 @default.
• W1996177248 doi "https://doi.org/10.1097/aln.0b013e3181dfd31b" @default.
• W1996177248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20613478" @default.
• W1996177248 hasPublicationYear "2010" @default.
• W1996177248 type Work @default.
• W1996177248 sameAs 1996177248 @default.
• W1996177248 citedByCount "30" @default.
• W1996177248 countsByYear W19961772482012 @default.
• W1996177248 countsByYear W19961772482013 @default.
• W1996177248 countsByYear W19961772482014 @default.
• W1996177248 countsByYear W19961772482015 @default.
• W1996177248 countsByYear W19961772482016 @default.
• W1996177248 countsByYear W19961772482017 @default.
• W1996177248 countsByYear W19961772482018 @default.
• W1996177248 countsByYear W19961772482019 @default.
• W1996177248 countsByYear W19961772482020 @default.
• W1996177248 countsByYear W19961772482021 @default.
• W1996177248 countsByYear W19961772482022 @default.
• W1996177248 countsByYear W19961772482023 @default.
• W1996177248 crossrefType "journal-article" @default.
• W1996177248 hasAuthorship W1996177248A5023017451 @default.
• W1996177248 hasAuthorship W1996177248A5025664510 @default.
• W1996177248 hasAuthorship W1996177248A5034752865 @default.
• W1996177248 hasAuthorship W1996177248A5053636583 @default.
• W1996177248 hasAuthorship W1996177248A5076741407 @default.
• W1996177248 hasAuthorship W1996177248A5087861405 @default.
• W1996177248 hasBestOaLocation W19961772481 @default.
• W1996177248 hasConcept C126322002 @default.
• W1996177248 hasConcept C141071460 @default.
• W1996177248 hasConcept C170493617 @default.
• W1996177248 hasConcept C197934379 @default.
• W1996177248 hasConcept C203014093 @default.
• W1996177248 hasConcept C2777063393 @default.
• W1996177248 hasConcept C2777397205 @default.
• W1996177248 hasConcept C2777610700 @default.
• W1996177248 hasConcept C2778468042 @default.
• W1996177248 hasConcept C2778994108 @default.
• W1996177248 hasConcept C2780149897 @default.
• W1996177248 hasConcept C2781328992 @default.
• W1996177248 hasConcept C42219234 @default.
• W1996177248 hasConcept C44575665 @default.
• W1996177248 hasConcept C7146039 @default.

• next