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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996180410> ?p ?o ?g. }

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• W1996180410 abstract "The effects of 5-, 5-lactone, 12- and 15-hydroxyeicosatetraenoic acids (HETEs) on the synthesis of leukotriene C4 (LTC4), thromboxane B2 (TxB2) and prostaglandin E2 (PGE2) by mouse resident peritoneal macrophages incubated with zymosan particles (100 μg/ml) were investigated. Zymosan phagocytosis stimulated a 110-, 16-, and 16-fold increase in LTC4, TxB2 and PGE2 synthesis, respectively. 15-HETE inhibited zymosan-induced LTC4 (IC50 = 1.1 μM) and TxB2 (IC50 = 38.9 μM) synthesis; in contrast, 15-HETE induced a consistent but variable enhancement of PGE2 synthesis. 5-HETE (IC50 = 15 μM), 5-lactone HETE (IC50 = 10.4 μM) and 12-HETE (IC50 = 13 μM) also inhibited LTC4 synthesis but they were approximately an order of magnitude less potent than 15-HETE. Furthermore, 5-HETE, 5-lactone HETE and 12-HETE inhibited TxB2 (IC50 = 20.4, 16.9 and 11.8 μM, respectively) and PGE2 (IC50 = 38.6, 2.3 and 11.6 μM, respectively) synthesis. Thus, monoHETEs exert modulatory actions on arachiodonic acid metabolism and the different isomers of HETE differ quantitavely and qualitatively in their actions." @default.
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• W1996180410 date "1985-01-01" @default.
• W1996180410 modified "2023-09-23" @default.
• W1996180410 title "Modulation by hydroxyeicosatetraenoic acids (HETEs) of arachidonic acid metabolism in mouse resident peritoneal macrophages" @default.
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• W1996180410 doi "https://doi.org/10.1016/0014-2999(85)90061-5" @default.
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