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• W1996194890 abstract "The present study provides data on fresh volumes of 39 anatomically defined brain regions after a 10 min transient forebrain ischemia in the rat. Ischemia was induced by occlusion of the carotid arteries and simultaneous hypotension. After a survival period of 3 months the rats were transcardially perfusion-fixed with Bodian's solution, and the brains processed for paraffin embedding and serially sectioned. The sections were Nissl-stained for delineation of the brain regions. The volume of a brain region was calculated from 8–10 equidistant sections, using the Cavalieri method and corrected for shrinkage of the brain. Fresh volumes were reduced by 27–50% in the layers of the hippocampal CA1 sector, by 40–46% in the substantia nigra, by 19% in the caudate nucleus, by 13% in the subiculum and the cingulate areas 1–3, by 12–14% in the retrosplenial and temporal areas. The results show that determination of fresh volumes is a sensitive method for quantification and localization of ischemic brain damage in the whole brain." @default.
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• W1996194890 date "1993-03-01" @default.
• W1996194890 modified "2023-09-27" @default.
• W1996194890 title "Assessing chronic brain damage by quantification of regional volumes in postischemic rat brains" @default.
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• W1996194890 doi "https://doi.org/10.1016/0006-8993(93)91751-d" @default.
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