FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996199571> ?p ?o ?g. }

• W1996199571 endingPage "1933" @default.
• W1996199571 startingPage "1924" @default.
• W1996199571 abstract "Abstract The present study shows that insulin-like growth factor I (IGF-I) and FSH receptor (FSHR) mRNAs are selectively coexpressed in a subset of healthy-appearing follicles in murine ovaries, irrespective of cycle stage. Aromatase gene expression, a prime marker for FSH effect, is found only in IGF-I/FSHR- positive follicles, showing that these are healthy, gonadotropin-responsive follicles. Given the striking coexpression of FSHR and IGF-I, we hypothesized that FSH was responsible for follicular IGF-I expression. We found, however, that granulosa cell IGF-I mRNA levels are not reduced in hypophysectomized (±PMSG) or FSH knockout mice, indicating that FSH does not have a major role in regulation of granulosa cell IGF-I gene expression. To test the alternative hypothesis that IGF-I regulates FSHR gene expression, we studied ovaries from IGF-I knockout mice. FSHR mRNA was significantly reduced in ovaries from homozygous IGF-I knockout compared with wild type mice and was restored to control values by exogenous IGF-I treatment. The functional significance of the reduced FSHR gene expression in IGF-I knockout ovaries is suggested by reduced aromatase expression and by the failure of their follicles to develop normally beyond the early antral stage. In fact, IGF-I knockout and FSH knockout ovaries appear very similar in terms of arrested follicular development. In summary, we have shown that IGF-I and FSHR are selectively coexpressed in healthy, growing murine follicles and that FSH does not affect IGF-I expression but that IGF-I augments granulosa cell FSHR expression. These data suggest that ovarian IGF-I expression serves to enhance granulosa cell FSH responsiveness by augmenting FSHR expression." @default.
• W1996199571 created "2016-06-24" @default.
• W1996199571 creator A5050632280 @default.
• W1996199571 creator A5065361249 @default.
• W1996199571 creator A5067118777 @default.
• W1996199571 creator A5082012698 @default.
• W1996199571 date "1997-12-01" @default.
• W1996199571 modified "2023-10-12" @default.
• W1996199571 title "Insulin-Like Growth Factor I Regulates Gonadotropin Responsiveness in the Murine Ovary" @default.
• W1996199571 cites W1755363571 @default.
• W1996199571 cites W1988438008 @default.
• W1996199571 cites W2000381423 @default.
• W1996199571 cites W2004208175 @default.
• W1996199571 cites W2008901904 @default.
• W1996199571 cites W2011927780 @default.
• W1996199571 cites W2014116250 @default.
• W1996199571 cites W2018831893 @default.
• W1996199571 cites W2031235337 @default.
• W1996199571 cites W2035519814 @default.
• W1996199571 cites W2039825798 @default.
• W1996199571 cites W2046826218 @default.
• W1996199571 cites W2050124019 @default.
• W1996199571 cites W2064298474 @default.
• W1996199571 cites W2065460036 @default.
• W1996199571 cites W2070466664 @default.
• W1996199571 cites W2092224562 @default.
• W1996199571 cites W2151007150 @default.
• W1996199571 cites W2158716468 @default.
• W1996199571 doi "https://doi.org/10.1210/mend.11.13.0032" @default.
• W1996199571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9415397" @default.
• W1996199571 hasPublicationYear "1997" @default.
• W1996199571 type Work @default.
• W1996199571 sameAs 1996199571 @default.
• W1996199571 citedByCount "202" @default.
• W1996199571 countsByYear W19961995712012 @default.
• W1996199571 countsByYear W19961995712013 @default.
• W1996199571 countsByYear W19961995712014 @default.
• W1996199571 countsByYear W19961995712015 @default.
• W1996199571 countsByYear W19961995712016 @default.
• W1996199571 countsByYear W19961995712017 @default.
• W1996199571 countsByYear W19961995712018 @default.
• W1996199571 countsByYear W19961995712019 @default.
• W1996199571 countsByYear W19961995712020 @default.
• W1996199571 countsByYear W19961995712021 @default.
• W1996199571 countsByYear W19961995712022 @default.
• W1996199571 countsByYear W19961995712023 @default.
• W1996199571 crossrefType "journal-article" @default.
• W1996199571 hasAuthorship W1996199571A5050632280 @default.
• W1996199571 hasAuthorship W1996199571A5065361249 @default.
• W1996199571 hasAuthorship W1996199571A5067118777 @default.
• W1996199571 hasAuthorship W1996199571A5082012698 @default.
• W1996199571 hasBestOaLocation W19961995711 @default.
• W1996199571 hasConcept C104317684 @default.
• W1996199571 hasConcept C121608353 @default.
• W1996199571 hasConcept C126322002 @default.
• W1996199571 hasConcept C134018914 @default.
• W1996199571 hasConcept C142773365 @default.
• W1996199571 hasConcept C150194340 @default.
• W1996199571 hasConcept C170493617 @default.
• W1996199571 hasConcept C182704531 @default.
• W1996199571 hasConcept C187785154 @default.
• W1996199571 hasConcept C2775960820 @default.
• W1996199571 hasConcept C2776166826 @default.
• W1996199571 hasConcept C2777203538 @default.
• W1996199571 hasConcept C2778324911 @default.
• W1996199571 hasConcept C2778575703 @default.
• W1996199571 hasConcept C2778782382 @default.
• W1996199571 hasConcept C2779279165 @default.
• W1996199571 hasConcept C2780689927 @default.
• W1996199571 hasConcept C29390026 @default.
• W1996199571 hasConcept C530470458 @default.
• W1996199571 hasConcept C54355233 @default.
• W1996199571 hasConcept C71315377 @default.
• W1996199571 hasConcept C71924100 @default.
• W1996199571 hasConcept C86803240 @default.
• W1996199571 hasConceptScore W1996199571C104317684 @default.
• W1996199571 hasConceptScore W1996199571C121608353 @default.
• W1996199571 hasConceptScore W1996199571C126322002 @default.
• W1996199571 hasConceptScore W1996199571C134018914 @default.
• W1996199571 hasConceptScore W1996199571C142773365 @default.
• W1996199571 hasConceptScore W1996199571C150194340 @default.
• W1996199571 hasConceptScore W1996199571C170493617 @default.
• W1996199571 hasConceptScore W1996199571C182704531 @default.
• W1996199571 hasConceptScore W1996199571C187785154 @default.
• W1996199571 hasConceptScore W1996199571C2775960820 @default.
• W1996199571 hasConceptScore W1996199571C2776166826 @default.
• W1996199571 hasConceptScore W1996199571C2777203538 @default.
• W1996199571 hasConceptScore W1996199571C2778324911 @default.
• W1996199571 hasConceptScore W1996199571C2778575703 @default.
• W1996199571 hasConceptScore W1996199571C2778782382 @default.
• W1996199571 hasConceptScore W1996199571C2779279165 @default.
• W1996199571 hasConceptScore W1996199571C2780689927 @default.
• W1996199571 hasConceptScore W1996199571C29390026 @default.
• W1996199571 hasConceptScore W1996199571C530470458 @default.
• W1996199571 hasConceptScore W1996199571C54355233 @default.
• W1996199571 hasConceptScore W1996199571C71315377 @default.
• W1996199571 hasConceptScore W1996199571C71924100 @default.
• W1996199571 hasConceptScore W1996199571C86803240 @default.

• next