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• W1996201844 endingPage "F721" @default.
• W1996201844 startingPage "F711" @default.
• W1996201844 abstract "Extracellular nucleotides, acting through the P2Y 2 receptor and the associated phosphoinositide-Ca 2 + signaling pathway, inhibit AVP-stimulated osmotic water permeability in rat inner medullary collecting duct (IMCD). Because a rise in intracellular Ca 2 + is frequently associated with enhanced arachidonic acid metabolism, we examined the effect of activation of the P2Y 2 receptor on release of PGE 2 in freshly prepared rat IMCD suspensions. Unstimulated IMCD released moderate, but significant, amounts of PGE 2 , which were more sensitive to cyclooxygenase (COX)-2 than COX-1 inhibition. Agonist activation of P2Y 2 receptor by adenosine 5′- O-(3-thiotriphosphate) enhanced release of PGE 2 from IMCD in a time- and concentration-dependent fashion. Purinergic-stimulated release of PGE 2 was completely blocked by nonspecific COX inhibitors (flurbiprofen and 2-acetoxyphenylhept-2-ynyl sulfide). Differential COX inhibition studies revealed that purinergic-stimulated release of PGE 2 was more sensitive to a COX-1-specific inhibitor (valeroyl salicylate) than a COX-2-specific inhibitor (NS-398). Thus purinergic stimulation resulted in significantly more release of PGE 2 in the presence of COX-2 inhibitor than COX-1 inhibitor. If it is assumed that increased release of PGE 2 is related to its increased production, our results suggest that purinergic stimulation of IMCD results in enhanced production and release of PGE 2 in a COX-1-dependent fashion. Because PGE 2 is known to affect transport of water, salt, and urea in IMCD, interaction of the purinergic system with the prostanoid system in IMCD can modulate handling of water, salt, and urea by IMCD and, thus, may constitute an AVP-independent regulatory mechanism." @default.
• W1996201844 created "2016-06-24" @default.
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• W1996201844 creator A5026039494 @default.
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• W1996201844 date "2003-10-01" @default.
• W1996201844 modified "2023-09-27" @default.
• W1996201844 title "P2Y₂ receptor-stimulated release of prostaglandin E₂ by rat inner medullary collecting duct preparations" @default.
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• W1996201844 doi "https://doi.org/10.1152/ajprenal.00096.2003" @default.
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