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- W1996201906 abstract "Abstract Aim To determine the value of clindamycin prophylaxis in the prevention of postoperative wound infections in patients undergoing endodontic surgery. Methodology This study included 256 patients undergoing endodontic surgery in a prospective double‐blind placebo‐controlled trial comparing oral administration of an oral placebo versus a preoperative 600 mg dose of clindamycin. After randomization the study medication was administered orally 1 h before surgery in a double‐blind fashion. For a period of 4 weeks the postoperative course was observed according to clinical parameters of infection. Primary end‐point was infection at the surgical site. Results The mean age of the study population was 44.4 years (SD 11.4, range 18–82 years) with a sex distribution of 147 females (47.4%) and 109 males (42.6%). Mean age of the patients in the clindamycin group was 44.7 years (SD 12.0), and the mean age in the placebo group was 44.1 years (SD 10.8) ( P = 0.49). In the clindamycin group, the mean duration of surgery was 32.3 min (SD 8.8) and in the placebo group the mean duration of surgery was 32.5 min (SD 8.4) ( P = 0.89). Two infections [1.6%; 95 confidence interval (CI): 0.48–4.72] were identified in the clindamycin group and four (3.2%; 95 CI: 0.42–1.33) in the placebo group ( P = 0.448). Conclusions No statistically significant difference was found between clindamycin prophylaxis and placebo with regard to the prevention of postoperative infection in endodontic surgical procedures." @default.
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- W1996201906 date "2005-11-22" @default.
- W1996201906 modified "2023-10-16" @default.
- W1996201906 title "The role of preoperative prophylactic antibiotic administration in periapical endodontic surgery: a randomized, prospective double‐blind placebo‐controlled study" @default.
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- W1996201906 doi "https://doi.org/10.1111/j.1365-2591.2005.01030.x" @default.
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