FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996202279> ?p ?o ?g. }

• W1996202279 endingPage "2500" @default.
• W1996202279 startingPage "2495" @default.
• W1996202279 abstract "In order to assess the possible role of human apurinic/apyrimidinic endonuclease (Ape) in double-strand break repair, the substrate specificity of this enzyme was investigated using short DNA duplexes and partial duplexes, each having a single 3'-phosphoglycolate terminus. Phosphoglycolate removal by Ape was detected as a shift in mobility of 5'-end-labeled DNA strands on polyacrylamide sequencing gels, and was quantified by phosphorimaging. Recombinant Ape efficiently removed phosphoglycolates from the 3'-terminus of an internal 1 base gap in a 38mer duplex, but acted more slowly on 3'-phosphoglycolates at a 19 base-recessed 3'-terminus, at an internal nick with no missing bases, and at a double-strand break end with either blunt or 2 base-recessed 3'-termini. There was no detectable activity of Ape toward 3'-phosphoglycolates on 1 or 2 base protruding single-stranded 3'-overhangs. The results suggest that both a single-base internal gap, and duplex DNA on each side of the gap are important binding/recognition determinants for Ape. While Ape may play a role in repair of terminally blocked double-strand breaks, there must also be additional factors involved in removal of at least some damaged 3'-termini, particularly those on 3'-overhangs." @default.
• W1996202279 created "2016-06-24" @default.
• W1996202279 creator A5043431590 @default.
• W1996202279 creator A5068693127 @default.
• W1996202279 creator A5090021812 @default.
• W1996202279 date "1997-06-01" @default.
• W1996202279 modified "2023-09-26" @default.
• W1996202279 title "3'-Phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends" @default.
• W1996202279 cites W1487427081 @default.
• W1996202279 cites W1511985622 @default.
• W1996202279 cites W1519057123 @default.
• W1996202279 cites W1560746966 @default.
• W1996202279 cites W1597233504 @default.
• W1996202279 cites W1602413253 @default.
• W1996202279 cites W1805451181 @default.
• W1996202279 cites W1949973946 @default.
• W1996202279 cites W1964616976 @default.
• W1996202279 cites W1974750292 @default.
• W1996202279 cites W1995568065 @default.
• W1996202279 cites W2004442904 @default.
• W1996202279 cites W2012579169 @default.
• W1996202279 cites W2014007312 @default.
• W1996202279 cites W2020134525 @default.
• W1996202279 cites W2028025897 @default.
• W1996202279 cites W2033609783 @default.
• W1996202279 cites W2033800372 @default.
• W1996202279 cites W2036542803 @default.
• W1996202279 cites W2040825860 @default.
• W1996202279 cites W2043687752 @default.
• W1996202279 cites W2044179656 @default.
• W1996202279 cites W2044461915 @default.
• W1996202279 cites W2062956078 @default.
• W1996202279 cites W2063847007 @default.
• W1996202279 cites W2069385594 @default.
• W1996202279 cites W2069909383 @default.
• W1996202279 cites W2073005211 @default.
• W1996202279 cites W2074964515 @default.
• W1996202279 cites W2075359803 @default.
• W1996202279 cites W2088177501 @default.
• W1996202279 cites W2095464964 @default.
• W1996202279 cites W2105908798 @default.
• W1996202279 cites W2135749989 @default.
• W1996202279 cites W2141980923 @default.
• W1996202279 cites W2149922717 @default.
• W1996202279 cites W2150281047 @default.
• W1996202279 cites W2159825246 @default.
• W1996202279 cites W2166775631 @default.
• W1996202279 cites W28829384 @default.
• W1996202279 doi "https://doi.org/10.1093/nar/25.12.2495" @default.
• W1996202279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/146737" @default.
• W1996202279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9171104" @default.
• W1996202279 hasPublicationYear "1997" @default.
• W1996202279 type Work @default.
• W1996202279 sameAs 1996202279 @default.
• W1996202279 citedByCount "162" @default.
• W1996202279 countsByYear W19962022792012 @default.
• W1996202279 countsByYear W19962022792013 @default.
• W1996202279 countsByYear W19962022792014 @default.
• W1996202279 countsByYear W19962022792015 @default.
• W1996202279 countsByYear W19962022792016 @default.
• W1996202279 countsByYear W19962022792017 @default.
• W1996202279 countsByYear W19962022792018 @default.
• W1996202279 countsByYear W19962022792019 @default.
• W1996202279 countsByYear W19962022792021 @default.
• W1996202279 countsByYear W19962022792022 @default.
• W1996202279 countsByYear W19962022792023 @default.
• W1996202279 crossrefType "journal-article" @default.
• W1996202279 hasAuthorship W1996202279A5043431590 @default.
• W1996202279 hasAuthorship W1996202279A5068693127 @default.
• W1996202279 hasAuthorship W1996202279A5090021812 @default.
• W1996202279 hasBestOaLocation W19962022792 @default.
• W1996202279 hasConcept C1009745 @default.
• W1996202279 hasConcept C104317684 @default.
• W1996202279 hasConcept C12554922 @default.
• W1996202279 hasConcept C129312508 @default.
• W1996202279 hasConcept C143425029 @default.
• W1996202279 hasConcept C150777479 @default.
• W1996202279 hasConcept C153911025 @default.
• W1996202279 hasConcept C185581394 @default.
• W1996202279 hasConcept C187206112 @default.
• W1996202279 hasConcept C2776435897 @default.
• W1996202279 hasConcept C2777028655 @default.
• W1996202279 hasConcept C40767141 @default.
• W1996202279 hasConcept C552990157 @default.
• W1996202279 hasConcept C55493867 @default.
• W1996202279 hasConcept C86803240 @default.
• W1996202279 hasConcept C99611785 @default.
• W1996202279 hasConceptScore W1996202279C1009745 @default.
• W1996202279 hasConceptScore W1996202279C104317684 @default.
• W1996202279 hasConceptScore W1996202279C12554922 @default.
• W1996202279 hasConceptScore W1996202279C129312508 @default.
• W1996202279 hasConceptScore W1996202279C143425029 @default.
• W1996202279 hasConceptScore W1996202279C150777479 @default.
• W1996202279 hasConceptScore W1996202279C153911025 @default.
• W1996202279 hasConceptScore W1996202279C185581394 @default.
• W1996202279 hasConceptScore W1996202279C187206112 @default.
• W1996202279 hasConceptScore W1996202279C2776435897 @default.
• W1996202279 hasConceptScore W1996202279C2777028655 @default.

• next