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• W1996208929 endingPage "5388" @default.
• W1996208929 startingPage "5382" @default.
• W1996208929 abstract "We examined the humoral immune response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein in mice following intranasal challenge at day 0 (primary) and day 21 (secondary) with subtype A (A2 strain) or B (B1 strain) RSV preparations. Our serological screening reagents included bacterially derived glutathione S-transferase (GST) fusion proteins, each bearing a portion of the RSV G central core (CC; residues 151–190), proximal central core (PCC; residues 151–172), and the distal central core (DCC; residues 173–190) and purified RSV G proteins from subtype A and B viruses. Convalescent sera collected on day 21 following primary RSV infection bore robust IgG response primarily against the homosubtypic RSV G DCC with relatively modest antigen affinity/avidity as demonstrated by brief incubation with 6 M urea. In contrast, sera collected on day 42 following secondary homosubtypic RSV infection bore IgG titers of higher magnitudes and antigen affinity/avidity against the homosubtypic RSV G CC, PCC, and/or the DCC regions and full-length RSV G protein but not against the heterosubtypic RSV G protein or recombinant CC subdomains. In contrast, heterosubtypic secondary RSV infection elicits a broad array of IgG responses with titers of varying magnitudes to homo- and heterosubtypic RSV G CC regions as well as to purified F, Ga, and Gb proteins with the notable exception of minimal response to the RSV G DCC domain associated with the secondary RSV challenge. Our results have implications for RSV G-based serological assays as well as prophylactic immunotherapy and RSV vaccine development." @default.
• W1996208929 created "2016-06-24" @default.
• W1996208929 creator A5027605987 @default.
• W1996208929 creator A5070084046 @default.
• W1996208929 date "2012-08-01" @default.
• W1996208929 modified "2023-10-18" @default.
• W1996208929 title "Antibody response to the central unglycosylated region of the respiratory syncytial virus attachment protein in mice" @default.
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• W1996208929 doi "https://doi.org/10.1016/j.vaccine.2012.06.016" @default.
• W1996208929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3401318" @default.
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