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- W1996213093 abstract "Abstract A series of 1-{2-(3-,4-)[1-oxidopyridinyl]}-1,2-epoxybutan-3-ones 13 and 1-[2-(3-,4-)pyridinyl]-1,2-epoxy-alkan-3-ones 12, 16 and 17 was synthesized. In vitro screening against L1210 leukemic cells indicated that thes tereochemistry of the oxiranyl substituents and/or size of the R 2 alkyl substituents are determinants of cytotoxic activity. Increasing the length of the R 2 alkyl substituent for trans-16 decreased activity. The lipophilic effect of the R 2 substituent does not appear to be a significant determinant of activity. Some structure—activity correlations are described." @default.
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- W1996213093 date "1988-01-01" @default.
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- W1996213093 title "Heterocyclic 1,2-epoxyalkan-3-ones as cytotoxic agents" @default.
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- W1996213093 doi "https://doi.org/10.1016/0223-5234(88)90165-1" @default.
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