FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996213758> ?p ?o ?g. }

• W1996213758 endingPage "3155" @default.
• W1996213758 startingPage "3152" @default.
• W1996213758 abstract "The orientation of the insect antibiotic peptide cecropin A (CecA) in the phospholipid bilayer membrane was determined using (15)N solid-state NMR spectroscopy. Two peptide samples, each specifically labeled with (15)N at Val(11) or Ala(27), were synthesized by solid phase techniques. The peptides were incorporated into phospholipid bilayers, prepared from a mixture of dimyristoylphosphatidylcholine and dimyristoylphosphatidylglycerol, and oriented on glass slides. The (15)N chemical shift solid-state NMR spectra from these uniaxially oriented samples display a single (15)N chemical shift frequency for each labeled residue. Both frequencies are near the upfield end of the (15)N chemical shift powder pattern, as expected for an alpha-helix with its long axis in the plane of the membrane and the NH bonds perpendicular to the direction of the magnetic field. These results support a mechanism of action in which CecA binds to and covers the membrane surface, thereby causing a general destabilization and leakiness of the lipid bilayer membrane. The data are discussed in relation to a proposed mechanism of membrane lysis and bacterial killing via an ion channel activity of CecA." @default.
• W1996213758 created "2016-06-24" @default.
• W1996213758 creator A5046677875 @default.
• W1996213758 creator A5063595434 @default.
• W1996213758 creator A5068083621 @default.
• W1996213758 creator A5073150317 @default.
• W1996213758 date "1999-12-01" @default.
• W1996213758 modified "2023-09-27" @default.
• W1996213758 title "Orientation of Cecropin A Helices in Phospholipid Bilayers Determined by Solid-State NMR Spectroscopy" @default.
• W1996213758 cites W1479939900 @default.
• W1996213758 cites W1497943846 @default.
• W1996213758 cites W1512985914 @default.
• W1996213758 cites W1539783664 @default.
• W1996213758 cites W1857017278 @default.
• W1996213758 cites W1964832767 @default.
• W1996213758 cites W1964840118 @default.
• W1996213758 cites W1965489457 @default.
• W1996213758 cites W1966552786 @default.
• W1996213758 cites W1972096102 @default.
• W1996213758 cites W1979325277 @default.
• W1996213758 cites W1988048149 @default.
• W1996213758 cites W1988884953 @default.
• W1996213758 cites W2000149654 @default.
• W1996213758 cites W2003560901 @default.
• W1996213758 cites W2010372934 @default.
• W1996213758 cites W2013962031 @default.
• W1996213758 cites W2039764190 @default.
• W1996213758 cites W2048893291 @default.
• W1996213758 cites W2050154603 @default.
• W1996213758 cites W2056976674 @default.
• W1996213758 cites W2059624134 @default.
• W1996213758 cites W2060752765 @default.
• W1996213758 cites W2069080599 @default.
• W1996213758 cites W2078173566 @default.
• W1996213758 cites W2087040299 @default.
• W1996213758 cites W2091585240 @default.
• W1996213758 cites W2102597392 @default.
• W1996213758 cites W2111940972 @default.
• W1996213758 cites W2130974803 @default.
• W1996213758 cites W2158789628 @default.
• W1996213758 cites W2225882279 @default.
• W1996213758 cites W2821065636 @default.
• W1996213758 cites W2953167866 @default.
• W1996213758 cites W64751791 @default.
• W1996213758 doi "https://doi.org/10.1016/s0006-3495(99)77145-6" @default.
• W1996213758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1300585" @default.
• W1996213758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10585936" @default.
• W1996213758 hasPublicationYear "1999" @default.
• W1996213758 type Work @default.
• W1996213758 sameAs 1996213758 @default.
• W1996213758 citedByCount "83" @default.
• W1996213758 countsByYear W19962137582013 @default.
• W1996213758 countsByYear W19962137582014 @default.
• W1996213758 countsByYear W19962137582015 @default.
• W1996213758 countsByYear W19962137582016 @default.
• W1996213758 countsByYear W19962137582017 @default.
• W1996213758 countsByYear W19962137582018 @default.
• W1996213758 countsByYear W19962137582019 @default.
• W1996213758 countsByYear W19962137582020 @default.
• W1996213758 countsByYear W19962137582021 @default.
• W1996213758 crossrefType "journal-article" @default.
• W1996213758 hasAuthorship W1996213758A5046677875 @default.
• W1996213758 hasAuthorship W1996213758A5063595434 @default.
• W1996213758 hasAuthorship W1996213758A5068083621 @default.
• W1996213758 hasAuthorship W1996213758A5073150317 @default.
• W1996213758 hasBestOaLocation W19962137581 @default.
• W1996213758 hasConcept C121332964 @default.
• W1996213758 hasConcept C12554922 @default.
• W1996213758 hasConcept C1276947 @default.
• W1996213758 hasConcept C153202636 @default.
• W1996213758 hasConcept C185592680 @default.
• W1996213758 hasConcept C192157962 @default.
• W1996213758 hasConcept C2777366737 @default.
• W1996213758 hasConcept C2778918659 @default.
• W1996213758 hasConcept C2779281246 @default.
• W1996213758 hasConcept C39944091 @default.
• W1996213758 hasConcept C41625074 @default.
• W1996213758 hasConcept C46141821 @default.
• W1996213758 hasConcept C4839761 @default.
• W1996213758 hasConcept C540938839 @default.
• W1996213758 hasConcept C55493867 @default.
• W1996213758 hasConcept C63491327 @default.
• W1996213758 hasConcept C66974803 @default.
• W1996213758 hasConcept C67787023 @default.
• W1996213758 hasConcept C71240020 @default.
• W1996213758 hasConcept C76564549 @default.
• W1996213758 hasConcept C8010536 @default.
• W1996213758 hasConcept C86803240 @default.
• W1996213758 hasConceptScore W1996213758C121332964 @default.
• W1996213758 hasConceptScore W1996213758C12554922 @default.
• W1996213758 hasConceptScore W1996213758C1276947 @default.
• W1996213758 hasConceptScore W1996213758C153202636 @default.
• W1996213758 hasConceptScore W1996213758C185592680 @default.
• W1996213758 hasConceptScore W1996213758C192157962 @default.
• W1996213758 hasConceptScore W1996213758C2777366737 @default.
• W1996213758 hasConceptScore W1996213758C2778918659 @default.
• W1996213758 hasConceptScore W1996213758C2779281246 @default.
• W1996213758 hasConceptScore W1996213758C39944091 @default.

• next