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- W1996224181 abstract "To the Editor: I read with great interest the article by Swaminathan et al.1.Swaminathan S. High W.A. Ranville J. et al.Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis.Kidney Int. 2008; 73: 1413-1418Abstract Full Text Full Text PDF PubMed Scopus (86) Google Scholar presenting the importance of high mortality in nephrogenic systemic fibrosis (NSF) and providing evidence that the short survival of these patients could be attributed to metal accumulation (gadolinium, aluminum, iron) in several inner organs, including heart and blood vessels. Although I completely agree with the authors, who wrote that they ‘…present several novel observations’ despite the fact that ‘there are several limitations’,1.Swaminathan S. High W.A. Ranville J. et al.Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis.Kidney Int. 2008; 73: 1413-1418Abstract Full Text Full Text PDF PubMed Scopus (86) Google Scholar some information is missing. For example, it would be interesting to know which Gd-containing contrast agents (GCCA) the patients received, and whether there was a difference in applied substances in patients who died and who are still alive. As previously described, both transmetalation of GCCA and association with NSF are preferentially observed along with nonionic linear compounds.2.Wiginton C.D. Kelly B. Oto A. et al.Gadolinium-based contrast exposure, nephrogenic systemic fibrosis, and gadolinium detection in tissue.AJR Am J Roentgenol. 2008; 190: 1060-1068Crossref PubMed Scopus (117) Google Scholar, 3.Abraham J.L. Thakral C. Skov L. et al.Dermal inorganic gadolinium concentrations: evidence for in vivo transmetallation and long-term persistence in nephrogenic systemic fibrosis.Br J Dermatol. 2008; 158: 273-280Crossref PubMed Scopus (160) Google Scholar, 4.Idée J.M. Port M. Medina C. et al.Possible involvement of gadolinium chelates in the pathophysiology of nephrogenic systemic fibrosis: A critical review.Toxicology. 2008; 248: 77-88Crossref PubMed Scopus (124) Google Scholar In contrast, macrocyclic compounds have up to now not been demonstrated as causing NSF.4.Idée J.M. Port M. Medina C. et al.Possible involvement of gadolinium chelates in the pathophysiology of nephrogenic systemic fibrosis: A critical review.Toxicology. 2008; 248: 77-88Crossref PubMed Scopus (124) Google Scholar Uncertainty about the chemical nature of GCCA used in patients who developed NSF and eventually died due to cardiac and vascular events limits our understanding of the disease and thus hampers efforts to prevent it. Furthermore, of the 32 patients with NSF studied, Table 1 presented only data of the 10 patients who died.1.Swaminathan S. High W.A. Ranville J. et al.Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis.Kidney Int. 2008; 73: 1413-1418Abstract Full Text Full Text PDF PubMed Scopus (86) Google Scholar What are the demographics, and clinical conditions of the 22 remaining patients? In particular, it would be very interesting to know whether these two groups were different in some aspect." @default.
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- W1996224181 date "2008-12-01" @default.
- W1996224181 modified "2023-10-17" @default.
- W1996224181 title "Does chemical structure of Gd-containing contrast agents contribute to mortality in nephrogenic systemic fibrosis?" @default.
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- W1996224181 doi "https://doi.org/10.1038/ki.2008.527" @default.
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