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- W1996225890 abstract "Interleukin 6 is an important peptide regulatory factor with diverse biological activities including stimulation of acute phase protein synthesis. In this report we describe the effect of signal transduction pathway modulators on interleukin 6 mediated acute phase protein synthesis in a human hepatoma cell line Hep G2. Genistein, a tyrosine kinase inhibitor inhibited the interleukin 6 stimulated synthesis of acute phase proteins suggesting that a tyrosine kinase event participates in the signal transduction pathway. There was no evidence to suggest that protein kinase C had a stimulatory role although this or a related kinase may be involved in down-regulating the interleukin 6 signal." @default.
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- W1996225890 date "1993-01-01" @default.
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- W1996225890 title "Interleukin 6 Signal Transduction in a Human Hepatoma Cell Line (Hep G2)" @default.
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- W1996225890 doi "https://doi.org/10.3109/08923979309035234" @default.
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