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- W1996230384 abstract "To investigate the relationship between changes in plasma concentrations of polymorphonuclear elastase (PMN-E) and haemostatic effects during haemodialysis (HD), changes in the plasma concentrations of elastase-alpha1 proteinase inhibitor complex (E-α1PI) and fibrinogen (Fbg), cross-linked fibrin degradation products (XDP), thrombin-antithrombin III complex (TAT), plasmin-α2 plasmin inhibitor complex (PIC) and soluble thrombomodulin (TM) in 49 patients with end-stage chronic glomerulonephritis maintained on chronic HD were measured. Plasma concentrations of TAT, PIC, TM and E-α1PI significantly increased during a single HD. There was a statistically significant correlation between change in plasma E-α1PI concentration and changes in plasma concentrations of TAT, PIC and TM during a single HD, as well as between changes in plasma concentrations of TM and TAT during a single HD. These observations suggested that activation of coagulation and fibrinolysis, endothelial cell damage, and activation of polymorphonuclear cells occur during HD. Activation of polymorphonuclear cells may induce activation of coagulation and fibrinolysis, leading to endothelial cell damage, augmented by release of proteases such as elastase." @default.
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- W1996230384 date "1995-02-01" @default.
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- W1996230384 title "Relationship between elevation in the plasma concentration of elastase-??1 proteinase inhibitor complex (E-??1PI) and haemostatic parameters during haemodialysis" @default.
- W1996230384 doi "https://doi.org/10.1097/00001721-199502000-00001" @default.
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