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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996236487> ?p ?o ?g. }

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• W1996236487 abstract "Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively.Visual analog scale (VAS) ratings of paranoia were obtained in 31 cocaine users during three cocaine self-administration sessions (8, 16, and 32 mg/70 kg). Pharmacogenetic interactions between cocaine and a putative functional polymorphism in DbetaH (-1021C-->T) were assessed.VAS self-ratings showed significant or trend-level interactions of genotype and time during each session (p = .004, .09 and .003, respectively) with TT homozygotes endorsing greater paranoia over time than either CT or CC individuals. Interactions were significant at all doses in African Americans (n = 19; p = .02, .04 and .05). No other demographic or experimental variable distinguished genotypic groups.Results indicate that individuals homozygous for the 'very low-activity' T allele at DbetaH -1021C-->T show an increased propensity to paranoia over time during cocaine self-administration." @default.
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• W1996236487 date "2007-06-01" @default.
• W1996236487 modified "2023-09-27" @default.
• W1996236487 title "Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration" @default.
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• W1996236487 doi "https://doi.org/10.1016/j.biopsych.2006.08.012" @default.
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