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• W1996241740 abstract "The microsomal triglyceride transfer protein (MTP) is involved in hepatic and intestinal apoB secretion. We studied the effect of the functional MTP−493G/T polymorphism on fasting and postprandial lipoproteins in patients with familial combined hyperlipidemia (FCH) before and after treatment with atorvastatin. Eight FCH heterozygote carriers of the rare −493T allele were compared to 9 matched FCH homozygotes for the wild-type allele in a pilot study. Oral fat loading tests were carried out to measure triglycerides (TG) and apo B48 and B100 in the different fractions of triglyceride-rich lipoproteins (TRLs) before and after treatment with atorvastatin. Before treatment, TG were similar between the −493T allele carriers and non-carriers. In the T-allele carriers, a trend was observed for increased postprandial apo B48 and B100 concentrations in Sf >400 and Sf 60–400 compared to non-carriers. After treatment, fasting and postprandial TG were significantly lowered in carriers of the T allele, but atorvastatin had no effect on postprandial TG in non-carriers. Atorvastatin resulted in similar reductions of apo B48 and B100 in TRLs in both groups. The MTP-493G/T polymorphism modulates postprandial apo B48 and apo B100 of TRLs in FCH. Atorvastatin decreases postprandial TG in T-allele carriers with FCH. La Microsomal Triglyceride Transfer Protein (MTP) participa en la secreción hepática e intestinal de apoB. Hemos estudiado el efecto del polimorfismo funcional MTP−493G/T sobre las lipoproteínas en ayunas o posprandiales en pacientes con hiperlipidemia familiar combinada (FCH) antes y después de un tratamiento con atorvastatina. Ocho pacientes FCH heterocigotos para el alelo menos frecuente −493T fueron comparados con 9 pacientes FCH homocigotos para el genotipo salvaje. Tras una sobrecarga oral de grasa se cuantificaron los triglicéridos (TG) y las apoB48 y apoB100 de las diferentes fracciones ricas en TG, antes y después del tratamiento con atorvastatina. Antes del tratamiento, los TG eran comparables entre portadores y no portadores del alelo −493T. En portadores del alelo T, se observó una tendencia a mayores concentraciones de apoB48 y apoB100 en las fracciones Sf >400 y Sf 60–400, comparado con los no portadores. Tras el tratamiento, los TG basales y posprandiales fueron significativamente más bajos en portadores del alelo T, pero la atorvastatina no tuvo efecto sobre los TG posprandiales en pacientes no portadores de −493T. La atorvastatina indujo disminuciones en apoB48 y apoB100 de las fracciones ricas en TG tanto en portadores como en no portadores. El polimorfismo -493G/T de la MTP modula el contenido en apoB48 y apoB100 de las lipoproteínas ricas en TG posprandiales. La atorvastatina disminuye los TG posprandiales en pacientes FCH portadores del alelo T." @default.
• W1996241740 created "2016-06-24" @default.
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• W1996241740 date "2014-03-01" @default.
• W1996241740 modified "2023-10-06" @default.
• W1996241740 title "MTP gene polymorphisms and postprandial lipemia in familial combined hyperlipidemia: Effects of treatment with atorvastatin" @default.
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• W1996241740 doi "https://doi.org/10.1016/j.arteri.2013.11.006" @default.
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