FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996248051> ?p ?o ?g. }

• W1996248051 endingPage "C726" @default.
• W1996248051 startingPage "C717" @default.
• W1996248051 abstract "Several studies have shown that nitric oxide (NO) inhibits Na + transport in renal and alveolar monolayers. However, the mechanisms by which NO alters epithelial Na + channel (ENaC) activity is unclear. Therefore, we examined the effect of applying the NO donor drug l-propanamine 3,2-hydroxy-2-nitroso-1-propylhidrazino (PAPA-NONOate) to cultured renal epithelial cells. A6 and M1 cells were maintained on permeable supports in medium containing 1.5 μM dexamethasone and 10% bovine serum. After 1.5 μM PAPA-NONOate was applied, amiloride-sensitive short-circuit current measurements decreased 29% in A6 cells and 44% in M1 cells. This differed significantly from the 3% and 19% decreases in A6 and M1 cells, respectively, treated with control donor compound ( P < 0.0005). Subsequent application of PAPA-NONOate to amiloride-treated control (no NONOate) A6 and M1 cells did not further decrease transepithelial current. In single-channel patch-clamp studies, NONOate significantly decreased ENaC open probability ( P o ) from 0.186 ± 0.043 to 0.045 ± 0.009 ( n = 7; P < 0.05) without changing the unitary current. We also showed that aldosterone significantly decreased NO production in primary cultures of alveolar type II (ATII) epithelial cells. Because inducible nitric oxide synthase (iNOS) coimmunoprecipitated with the serum- and glucocorticoid-inducible kinase (SGK1) and both proteins colocalized in the cytoplasm (as shown in our studies in mouse ATII cells), SGK1 may also be important in regulating NO production in the alveolar epithelium. Our study also identified iNOS as a novel SGK1 phosphorylated protein (at S733 and S903 residues in miNOS) suggesting that one way in which SGK1 could increase Na + transport is by altering iNOS production of NO." @default.
• W1996248051 created "2016-06-24" @default.
• W1996248051 creator A5002349409 @default.
• W1996248051 creator A5011330888 @default.
• W1996248051 creator A5015064187 @default.
• W1996248051 creator A5028548827 @default.
• W1996248051 creator A5044620477 @default.
• W1996248051 creator A5070874745 @default.
• W1996248051 date "2005-09-01" @default.
• W1996248051 modified "2023-10-15" @default.
• W1996248051 title "Role of SGK1 in nitric oxide inhibition of ENaC in Na⁺-transporting epithelia" @default.
• W1996248051 cites W1646747014 @default.
• W1996248051 cites W1897522638 @default.
• W1996248051 cites W1906410030 @default.
• W1996248051 cites W1925196084 @default.
• W1996248051 cites W1965857677 @default.
• W1996248051 cites W1970135715 @default.
• W1996248051 cites W1977180767 @default.
• W1996248051 cites W1977518774 @default.
• W1996248051 cites W1984780819 @default.
• W1996248051 cites W1991509186 @default.
• W1996248051 cites W1992700829 @default.
• W1996248051 cites W1995820290 @default.
• W1996248051 cites W1996254150 @default.
• W1996248051 cites W2003969706 @default.
• W1996248051 cites W2012329129 @default.
• W1996248051 cites W2015848852 @default.
• W1996248051 cites W2023784516 @default.
• W1996248051 cites W2024714829 @default.
• W1996248051 cites W2037028807 @default.
• W1996248051 cites W2042920634 @default.
• W1996248051 cites W2056299757 @default.
• W1996248051 cites W2063874865 @default.
• W1996248051 cites W2069019011 @default.
• W1996248051 cites W2076629036 @default.
• W1996248051 cites W2084224718 @default.
• W1996248051 cites W2087499467 @default.
• W1996248051 cites W2098009074 @default.
• W1996248051 cites W2107645950 @default.
• W1996248051 cites W2110119449 @default.
• W1996248051 cites W2124097655 @default.
• W1996248051 cites W2132199758 @default.
• W1996248051 cites W2136901254 @default.
• W1996248051 cites W2149045564 @default.
• W1996248051 cites W2158297122 @default.
• W1996248051 cites W2162193671 @default.
• W1996248051 cites W2167663952 @default.
• W1996248051 cites W2169494292 @default.
• W1996248051 cites W2169902680 @default.
• W1996248051 cites W2283215425 @default.
• W1996248051 cites W2283921235 @default.
• W1996248051 cites W2312324067 @default.
• W1996248051 cites W2418938762 @default.
• W1996248051 cites W4249696587 @default.
• W1996248051 cites W4253861185 @default.
• W1996248051 doi "https://doi.org/10.1152/ajpcell.00006.2005" @default.
• W1996248051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15843443" @default.
• W1996248051 hasPublicationYear "2005" @default.
• W1996248051 type Work @default.
• W1996248051 sameAs 1996248051 @default.
• W1996248051 citedByCount "57" @default.
• W1996248051 countsByYear W19962480512012 @default.
• W1996248051 countsByYear W19962480512013 @default.
• W1996248051 countsByYear W19962480512014 @default.
• W1996248051 countsByYear W19962480512015 @default.
• W1996248051 countsByYear W19962480512016 @default.
• W1996248051 countsByYear W19962480512017 @default.
• W1996248051 countsByYear W19962480512018 @default.
• W1996248051 countsByYear W19962480512019 @default.
• W1996248051 countsByYear W19962480512020 @default.
• W1996248051 countsByYear W19962480512021 @default.
• W1996248051 countsByYear W19962480512022 @default.
• W1996248051 crossrefType "journal-article" @default.
• W1996248051 hasAuthorship W1996248051A5002349409 @default.
• W1996248051 hasAuthorship W1996248051A5011330888 @default.
• W1996248051 hasAuthorship W1996248051A5015064187 @default.
• W1996248051 hasAuthorship W1996248051A5028548827 @default.
• W1996248051 hasAuthorship W1996248051A5044620477 @default.
• W1996248051 hasAuthorship W1996248051A5070874745 @default.
• W1996248051 hasConcept C126322002 @default.
• W1996248051 hasConcept C134018914 @default.
• W1996248051 hasConcept C142724271 @default.
• W1996248051 hasConcept C153911025 @default.
• W1996248051 hasConcept C178790620 @default.
• W1996248051 hasConcept C184150571 @default.
• W1996248051 hasConcept C185592680 @default.
• W1996248051 hasConcept C2777622882 @default.
• W1996248051 hasConcept C2778525890 @default.
• W1996248051 hasConcept C2779608910 @default.
• W1996248051 hasConcept C2780841215 @default.
• W1996248051 hasConcept C41625074 @default.
• W1996248051 hasConcept C519581460 @default.
• W1996248051 hasConcept C529295009 @default.
• W1996248051 hasConcept C537181965 @default.
• W1996248051 hasConcept C55493867 @default.
• W1996248051 hasConcept C6507245 @default.
• W1996248051 hasConcept C71924100 @default.
• W1996248051 hasConcept C86803240 @default.

• next