Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996249860> ?p ?o ?g. }
- W1996249860 endingPage "866" @default.
- W1996249860 startingPage "860" @default.
- W1996249860 abstract "Both the parasympathetic and sympathoadrenal inputs to the pancreas can stimulate glucagon release and are activated during hypoglycemia. However, blockade of only one branch of the autonomic nervous system may not reduce hypoglycemia-induced glucagon secretion, because the unblocked neural input is sufficient to mediate the glucagon response, ie, the neural inputs are redundant. Therefore, to determine if parasympathetic and sympathoadrenal activation redundantly mediate increased glucagon secretion during hypoglycemia, insulin was administered to conscious rats pretreated with a muscarinic antagonist (methylatropine, n = 7), combined α- and β-adrenergic receptor blockade (tolazoline + propranolol, n = 5), or adrenergic blockade + methylatropine (n = 7). Insulin administration produced similar hypoglycemia in control and antagonist-treated rats (25 to 32 mg/dL). In control rats (n = 9), plasma immunoreactive glucagon (IRG) increased from a baseline level of 125 ± 11 to 1,102 ± 102 pg/mL during hypoglycemia (ΔIRG = +977 ± 98 pg/mL, P < .0005). The plasma IRG response was not significantly altered either by methylatropine (ΔIRG = +677 ± 141 pg/mL) or by adrenergic blockade (ΔIRG = +1,374 ± 314 pg/mL). However, the IRG response to hypoglycemia was reduced to 25% of the control value by the combination of adrenergic blockade + methylatropine (ΔIRG = +250 ± 83 pg/mL, P < .01 v control rats). These results suggest that the plasma glucagon response to hypoglycemia in conscious rats is predominately the result of autonomic neural activation, and is redundantly mediated by the parasympathetic and sympathoadrenal divisions of the autonomic nervous system." @default.
- W1996249860 created "2016-06-24" @default.
- W1996249860 creator A5005961550 @default.
- W1996249860 creator A5009788566 @default.
- W1996249860 creator A5024887734 @default.
- W1996249860 creator A5034829692 @default.
- W1996249860 creator A5035495914 @default.
- W1996249860 creator A5051083156 @default.
- W1996249860 creator A5058774046 @default.
- W1996249860 date "1994-07-01" @default.
- W1996249860 modified "2023-10-18" @default.
- W1996249860 title "Redundant parasympathetic and sympathoadrenal mediation of increased glucagon secretion during insulin-induced hypoglycemia in conscious rats" @default.
- W1996249860 cites W114211259 @default.
- W1996249860 cites W1600232156 @default.
- W1996249860 cites W1895952682 @default.
- W1996249860 cites W1972081418 @default.
- W1996249860 cites W1974734676 @default.
- W1996249860 cites W1976922995 @default.
- W1996249860 cites W1977225925 @default.
- W1996249860 cites W1977970397 @default.
- W1996249860 cites W1980093709 @default.
- W1996249860 cites W1989261441 @default.
- W1996249860 cites W1989648370 @default.
- W1996249860 cites W2002848742 @default.
- W1996249860 cites W2004449713 @default.
- W1996249860 cites W2010193394 @default.
- W1996249860 cites W2016742506 @default.
- W1996249860 cites W2018436975 @default.
- W1996249860 cites W2024234930 @default.
- W1996249860 cites W2028078843 @default.
- W1996249860 cites W2036919573 @default.
- W1996249860 cites W2039929469 @default.
- W1996249860 cites W2041426566 @default.
- W1996249860 cites W2052062999 @default.
- W1996249860 cites W2066048438 @default.
- W1996249860 cites W2075962195 @default.
- W1996249860 cites W2102764257 @default.
- W1996249860 cites W2108133991 @default.
- W1996249860 cites W2114979370 @default.
- W1996249860 cites W2166554780 @default.
- W1996249860 cites W2178951657 @default.
- W1996249860 cites W2319728719 @default.
- W1996249860 cites W4236782362 @default.
- W1996249860 cites W4237309809 @default.
- W1996249860 cites W4248953975 @default.
- W1996249860 cites W4249638153 @default.
- W1996249860 cites W4251276112 @default.
- W1996249860 doi "https://doi.org/10.1016/0026-0495(94)90267-4" @default.
- W1996249860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8028509" @default.
- W1996249860 hasPublicationYear "1994" @default.
- W1996249860 type Work @default.
- W1996249860 sameAs 1996249860 @default.
- W1996249860 citedByCount "36" @default.
- W1996249860 countsByYear W19962498602012 @default.
- W1996249860 countsByYear W19962498602013 @default.
- W1996249860 countsByYear W19962498602014 @default.
- W1996249860 countsByYear W19962498602020 @default.
- W1996249860 countsByYear W19962498602022 @default.
- W1996249860 countsByYear W19962498602023 @default.
- W1996249860 crossrefType "journal-article" @default.
- W1996249860 hasAuthorship W1996249860A5005961550 @default.
- W1996249860 hasAuthorship W1996249860A5009788566 @default.
- W1996249860 hasAuthorship W1996249860A5024887734 @default.
- W1996249860 hasAuthorship W1996249860A5034829692 @default.
- W1996249860 hasAuthorship W1996249860A5035495914 @default.
- W1996249860 hasAuthorship W1996249860A5051083156 @default.
- W1996249860 hasAuthorship W1996249860A5058774046 @default.
- W1996249860 hasBestOaLocation W19962498602 @default.
- W1996249860 hasConcept C126322002 @default.
- W1996249860 hasConcept C134018914 @default.
- W1996249860 hasConcept C158453852 @default.
- W1996249860 hasConcept C170493617 @default.
- W1996249860 hasConcept C2775859304 @default.
- W1996249860 hasConcept C2776394411 @default.
- W1996249860 hasConcept C2776533406 @default.
- W1996249860 hasConcept C2777372248 @default.
- W1996249860 hasConcept C2777953023 @default.
- W1996249860 hasConcept C2778151854 @default.
- W1996249860 hasConcept C2778563252 @default.
- W1996249860 hasConcept C2779306644 @default.
- W1996249860 hasConcept C2780668416 @default.
- W1996249860 hasConcept C2908748658 @default.
- W1996249860 hasConcept C71924100 @default.
- W1996249860 hasConcept C84393581 @default.
- W1996249860 hasConceptScore W1996249860C126322002 @default.
- W1996249860 hasConceptScore W1996249860C134018914 @default.
- W1996249860 hasConceptScore W1996249860C158453852 @default.
- W1996249860 hasConceptScore W1996249860C170493617 @default.
- W1996249860 hasConceptScore W1996249860C2775859304 @default.
- W1996249860 hasConceptScore W1996249860C2776394411 @default.
- W1996249860 hasConceptScore W1996249860C2776533406 @default.
- W1996249860 hasConceptScore W1996249860C2777372248 @default.
- W1996249860 hasConceptScore W1996249860C2777953023 @default.
- W1996249860 hasConceptScore W1996249860C2778151854 @default.
- W1996249860 hasConceptScore W1996249860C2778563252 @default.
- W1996249860 hasConceptScore W1996249860C2779306644 @default.
- W1996249860 hasConceptScore W1996249860C2780668416 @default.
- W1996249860 hasConceptScore W1996249860C2908748658 @default.