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- W1996263489 abstract "Because mast cells (MCs) in skin of atopic dogs are heterogeneous with respect to tissue fixation and staining properties, we determined the effect of antigen on each type of MC in vivo. Skin biopsies were done in anesthetized, ragweed-sensitized dogs before and at 1, 3, 6, and 24 hours after intradermal injections of ragweed antigen (n = 5) or glycerin diluent (n = 4). In each case, one biopsy specimen was fixed with formalin, and a second specimen from an adjacent abdominal site was fixed with basic lead acetate. In sections stained with Alcian blue, 49.7% more MCs (p less than 0.05) were detected in tissue fixed with basic lead acetate (typical plus atypical MCs: 2916 +/- 581/mm3; mean +/- SEM) than in tissue fixed with formalin (typical MCs: 1955 +/- 537/mm3). After antigen, the number of typical MCs detectable in tissue sections progressively decreased during the 24-hour period, whereas the number of atypical MCs was lowest at 1 hour and had increased at 24 hours. After diluent, MC numbers did not change significantly over time. A late-phase response (LPR), detected clinically as induration and edema, was present 6 hours after antigen in four of five dogs, but LPR was not detected after diluent. The size of LPR was correlated (r = 0.85; p less than 0.05) with the decrease in the number of typical MCs at 6 hours. We conclude that the response of the typical and atypical MC to antigen in vivo differs markedly. The atypical MCs participate in the early, acute response to antigen, and the typical MCs may be associated with the development of the LPR." @default.
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- W1996263489 date "1986-11-01" @default.
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- W1996263489 title "Cutaneous mast cell heterogeneity: Response to antigen in atopic dogs" @default.
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- W1996263489 doi "https://doi.org/10.1016/0091-6749(86)90243-5" @default.
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