Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996264047> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1996264047 endingPage "717" @default.
- W1996264047 startingPage "714" @default.
- W1996264047 abstract "The BCR-ABL T315I mutation causes resistance to imatinib, nilotinib and dasatinib in chronic myeloid leukemia. Forty BCR-ABL positive patients with imatinib resistance were analyzed for T315I mutated clones after six months on nilotinib or dasatinib treatment by quantitative allele-specific ligation polymerase chain reaction with a sensitivity of 0.05%. Ligation polymerase chain reaction revealed 10 patients with more than 10(-5) BCR-ABL(T315I%)/GUS (high levels), none of whom achieved major molecular response after 12 months, and a further 8 patients with 10(-5) or below BCR-ABL(T315I%)/GUS (low levels) who all achieved major molecular response (P<0.001). A second independent group showed molecular response in one of 12 patients with high levels and 5 of 8 patients with low levels (P=0.018). Combining the groups resulted in a sensitivity and specificity of 92.9% and 87.5%, respectively. We conclude that the quantitative level of mutant T315I allele is predictive of major molecular response at 12 months on second-line nilotinib or dasatinib treatment. www.clinicaltrials.gov: CT00109707, NCT00384228, CA180013, CA180005 CA180006." @default.
- W1996264047 created "2016-06-24" @default.
- W1996264047 creator A5035964802 @default.
- W1996264047 creator A5038048953 @default.
- W1996264047 creator A5042734609 @default.
- W1996264047 creator A5055821837 @default.
- W1996264047 creator A5057695659 @default.
- W1996264047 creator A5061019774 @default.
- W1996264047 creator A5066994665 @default.
- W1996264047 creator A5088450042 @default.
- W1996264047 creator A5090119518 @default.
- W1996264047 date "2012-10-12" @default.
- W1996264047 modified "2023-09-26" @default.
- W1996264047 title "The quantitative level of T315I mutated BCR-ABL predicts for major molecular response to second-line nilotinib or dasatinib treatment in patients with chronic myeloid leukemia" @default.
- W1996264047 cites W1995670055 @default.
- W1996264047 cites W1999614615 @default.
- W1996264047 cites W2002473554 @default.
- W1996264047 cites W2016511622 @default.
- W1996264047 cites W2016809033 @default.
- W1996264047 cites W2024131016 @default.
- W1996264047 cites W2074740152 @default.
- W1996264047 cites W2076736727 @default.
- W1996264047 cites W2087724329 @default.
- W1996264047 cites W2091423586 @default.
- W1996264047 cites W2125690817 @default.
- W1996264047 cites W2166654361 @default.
- W1996264047 cites W2167087359 @default.
- W1996264047 cites W2167829945 @default.
- W1996264047 cites W2171499093 @default.
- W1996264047 cites W65831105 @default.
- W1996264047 doi "https://doi.org/10.3324/haematol.2012.068890" @default.
- W1996264047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3640114" @default.
- W1996264047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23065514" @default.
- W1996264047 hasPublicationYear "2012" @default.
- W1996264047 type Work @default.
- W1996264047 sameAs 1996264047 @default.
- W1996264047 citedByCount "19" @default.
- W1996264047 countsByYear W19962640472013 @default.
- W1996264047 countsByYear W19962640472014 @default.
- W1996264047 countsByYear W19962640472015 @default.
- W1996264047 countsByYear W19962640472016 @default.
- W1996264047 countsByYear W19962640472018 @default.
- W1996264047 countsByYear W19962640472022 @default.
- W1996264047 crossrefType "journal-article" @default.
- W1996264047 hasAuthorship W1996264047A5035964802 @default.
- W1996264047 hasAuthorship W1996264047A5038048953 @default.
- W1996264047 hasAuthorship W1996264047A5042734609 @default.
- W1996264047 hasAuthorship W1996264047A5055821837 @default.
- W1996264047 hasAuthorship W1996264047A5057695659 @default.
- W1996264047 hasAuthorship W1996264047A5061019774 @default.
- W1996264047 hasAuthorship W1996264047A5066994665 @default.
- W1996264047 hasAuthorship W1996264047A5088450042 @default.
- W1996264047 hasAuthorship W1996264047A5090119518 @default.
- W1996264047 hasBestOaLocation W19962640471 @default.
- W1996264047 hasConcept C126322002 @default.
- W1996264047 hasConcept C203014093 @default.
- W1996264047 hasConcept C2777413986 @default.
- W1996264047 hasConcept C2777583451 @default.
- W1996264047 hasConcept C2778729363 @default.
- W1996264047 hasConcept C2779536868 @default.
- W1996264047 hasConcept C502942594 @default.
- W1996264047 hasConcept C71924100 @default.
- W1996264047 hasConceptScore W1996264047C126322002 @default.
- W1996264047 hasConceptScore W1996264047C203014093 @default.
- W1996264047 hasConceptScore W1996264047C2777413986 @default.
- W1996264047 hasConceptScore W1996264047C2777583451 @default.
- W1996264047 hasConceptScore W1996264047C2778729363 @default.
- W1996264047 hasConceptScore W1996264047C2779536868 @default.
- W1996264047 hasConceptScore W1996264047C502942594 @default.
- W1996264047 hasConceptScore W1996264047C71924100 @default.
- W1996264047 hasIssue "5" @default.
- W1996264047 hasLocation W19962640471 @default.
- W1996264047 hasLocation W19962640472 @default.
- W1996264047 hasLocation W19962640473 @default.
- W1996264047 hasLocation W19962640474 @default.
- W1996264047 hasLocation W19962640475 @default.
- W1996264047 hasOpenAccess W1996264047 @default.
- W1996264047 hasPrimaryLocation W19962640471 @default.
- W1996264047 hasRelatedWork W2015725530 @default.
- W1996264047 hasRelatedWork W2055551175 @default.
- W1996264047 hasRelatedWork W2060584185 @default.
- W1996264047 hasRelatedWork W2080418768 @default.
- W1996264047 hasRelatedWork W2163329109 @default.
- W1996264047 hasRelatedWork W2266796555 @default.
- W1996264047 hasRelatedWork W2306349432 @default.
- W1996264047 hasRelatedWork W2321213113 @default.
- W1996264047 hasRelatedWork W2413578235 @default.
- W1996264047 hasRelatedWork W2540891876 @default.
- W1996264047 hasVolume "98" @default.
- W1996264047 isParatext "false" @default.
- W1996264047 isRetracted "false" @default.
- W1996264047 magId "1996264047" @default.
- W1996264047 workType "article" @default.