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• W1996268868 abstract "Since the presence of serum in culture media has been shown to alter prostaglandin production, as well as to interfere with the action of anti-inflammatory drugs, we have studied the effect of dexamethasone, a potent steroidal anti-inflammatory drug, on the metabolism of arachidonic acid by human monocyte-like cells (U937) grown in a fully defined medium. Under these culture conditions, dexamethasone (10(-6) M, 24 h) induced a marked stimulation of the release of unmetabolized arachidonic acid into the culture medium. The steroid also induced an inhibition of cell proliferation which became significant only after 48 h of treatment. The accumulation of arachidonic acid in the medium after steroid treatment was associated with a significant inhibition of cell acyltransferase activity, suggesting that steroids may also act upon arachidonic acid metabolism at sites other than those of phospholipase activity." @default.
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• W1996268868 date "1986-07-01" @default.
• W1996268868 modified "2023-09-24" @default.
• W1996268868 title "Dexamethasone-induced stimulation of arachidonic acid release by U937 cells grown in defined medium" @default.
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• W1996268868 doi "https://doi.org/10.1016/0167-4889(86)90056-x" @default.
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• W1996268868 hasPublicationYear "1986" @default.
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