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• W1996272285 abstract "We here consider the null distribution of the maximum lod score (LOD-M) obtained upon maximizing over transmission model parameters (penetrance values, dominance, and allele frequency) as well as the recombination fraction. Also considered is the lod score maximized over a fixed choice of genetic model parameters and recombination-fraction values set prior to the analysis (MMLS) as proposed by Hodge et al. [1]. The objective is to fit parametric distributions to MMLS and LOD-M. Our results are based on 3,600 simulations of samples of n = 100 nuclear families ascertained for having one affected member and at least one other sibling available for linkage analysis. Each null distribution is approximately a mixture p2₀ + (1 – p)2v. The values of MMLS appear to fit the mixture 0.202₀ + 0.80χ21.6. The mixture distribution 0.132₀ + 0.87χ22.8. appears to describe the null distribution of LOD-M. From these results we derive a simple method for obtaining critical values of LOD-M and MMLS." @default.
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• W1996272285 date "2004-05-07" @default.
• W1996272285 modified "2023-09-25" @default.
• W1996272285 title "Percentiles of the Null Distribution of 2 Maximum Lod Score Tests" @default.
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• W1996272285 doi "https://doi.org/10.1159/000077388" @default.
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