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• W1996272298 abstract "Objective: To determine if metformin therapy improves in vitro fertilization (IVF) outcomes in patients with clomiphene-resistant polycystic ovarian syndrome (PCOS).Design: Retrospective data analysis of selective groups of patients.Setting: A private IVF unit.Patient(s): Forty-six women with clomiphene citrate–resistant PCOS underwent 60 cycles of IVF embryo transfer with intracytoplasmic sperm injection.Intervention(s): In half of the cycles, patients received metformin (1000 to 1500 mg) daily, starting the cycle prior to gonadotropin treatment.Main Outcome Measure(s): Total number of follicles; serum estradiol (E2) on the day of hCG administration and the cycle’s E2 maximum; total number of oocytes, mature oocytes, embryos, fertilization, and pregnancy rates; and follicular fluid levels of insulin-like growth factors (IGF-I, IGF-II) and IGF-binding proteins (IGFBP-1, IGFBP-3).Result(s): In patients treated with metformin, the total number of follicles on the day of hCG treatment was decreased (23 ± 1.2 vs. 33 ± 2.6) with no change in follicles ≥14 mm in diameter (21 ± 1.2 vs. 25 ± 1.7). Metformin treatment did not affect the mean number of oocytes retrieved (22 ± 1.9 vs. 20.3 ± 1.5). However, the mean number of mature oocytes (18.4 ± 1.5 vs. 13 ± 1.5) and embryos cleaved (12.5 ± 1.5 vs. 5.9 ± 0.9) were increased after metformin treatment. Fertilization rates (64% vs. 43%) and clinical pregnancy rates (70% vs.30%) were also increased. Metformin led to modulation of preovulatory of follicular fluid IGF levels with increases of IGF-I (140 ± 8 vs. 109 ± 7ng/mL) and decreased of IGFBP-1 (133 ± 8 vs.153 ± 9ng/mL).Conclusion(s): Metformin use appears to improve IVF outcomes in patients with clomiphene citrate–resistant PCOS." @default.
• W1996272298 created "2016-06-24" @default.
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• W1996272298 date "2001-03-01" @default.
• W1996272298 modified "2023-09-26" @default.
• W1996272298 title "Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors" @default.
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• W1996272298 doi "https://doi.org/10.1016/s0015-0282(00)01766-0" @default.
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