FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996276518> ?p ?o ?g. }

• W1996276518 endingPage "101" @default.
• W1996276518 startingPage "93" @default.
• W1996276518 abstract "Collagen-induced arthritis (CIA) is an experimental model of rheumatoid arthritis (RA) and has aided research into the pathogenesis of inflammatory joint disease. Typically, Type II collagen (CII) emulsified with Freund's complete adjuvant (FCA) is injected into DBA/1 mice. After a booster injection, the mice develop inflammation of the paws. But the fact that the immunization of CII alone does not induce arthritis suggests that activation of the immune system by an adjuvant is necessary for induction of the arthritis. In the present study, we investigated the ability of beta-glucans derived from Candida albicans to act as an adjuvant to induce autoimmune arthritis. DBA/1 mice were injected with CII emulsified with FCA or particulate beta-glucan, OX-CA, on day 0 and given a booster at day 21. Mice immunized with CII plus OX-CA developed arthritis at around 7-10 days after the booster injection. Similarly, mice administered CII emulsified with FCA developed arthritis with the same time course. The mice immunized with CII and OX-CA had a more severe arthritis than those immunized with CII and FCA. Histological changes and production of anti-CII antibody were observed regardless of the type of injection. In addition, components of C. albicans were also tested for their ability to induce arthritis as an adjuvant. The results showed that CSBG, which is a soluble beta-glucan, acted as an adjuvant for CIA but CAWS, which is a mannoprotein-beta-glucan complex, did not. In conclusion, beta-glucan derived from C. albicans acted as an adjuvant and the injection with CII resulted in arthritis with the production of anti-CII autoantibody. The results strongly suggested that fungal metabolites such as beta-glucans have the capacity to induce and exacerbate autoimmune diseases such as RA." @default.
• W1996276518 created "2016-06-24" @default.
• W1996276518 creator A5047326414 @default.
• W1996276518 creator A5060130752 @default.
• W1996276518 creator A5076929039 @default.
• W1996276518 creator A5089372835 @default.
• W1996276518 date "2005-09-01" @default.
• W1996276518 modified "2023-09-25" @default.
• W1996276518 title "Effect of Candida albicans cell wall glucan as adjuvant for induction of autoimmune arthritis in mice" @default.
• W1996276518 cites W1913496425 @default.
• W1996276518 cites W1964653776 @default.
• W1996276518 cites W1968645163 @default.
• W1996276518 cites W1969429597 @default.
• W1996276518 cites W1973266941 @default.
• W1996276518 cites W1973406875 @default.
• W1996276518 cites W1976912963 @default.
• W1996276518 cites W1980990177 @default.
• W1996276518 cites W1988940275 @default.
• W1996276518 cites W1990405006 @default.
• W1996276518 cites W1990645826 @default.
• W1996276518 cites W1999275802 @default.
• W1996276518 cites W2002611996 @default.
• W1996276518 cites W2003777964 @default.
• W1996276518 cites W2010207538 @default.
• W1996276518 cites W2035073858 @default.
• W1996276518 cites W2047001651 @default.
• W1996276518 cites W2048694382 @default.
• W1996276518 cites W2049102738 @default.
• W1996276518 cites W2053290566 @default.
• W1996276518 cites W2060731274 @default.
• W1996276518 cites W2065054650 @default.
• W1996276518 cites W2068574855 @default.
• W1996276518 cites W2073501257 @default.
• W1996276518 cites W2075431973 @default.
• W1996276518 cites W2082566286 @default.
• W1996276518 cites W2085853581 @default.
• W1996276518 cites W2098790011 @default.
• W1996276518 cites W2101163917 @default.
• W1996276518 cites W2107531246 @default.
• W1996276518 cites W2108093856 @default.
• W1996276518 cites W2126924404 @default.
• W1996276518 cites W2126924958 @default.
• W1996276518 cites W2137016741 @default.
• W1996276518 cites W2161446243 @default.
• W1996276518 cites W2175666958 @default.
• W1996276518 cites W2334452506 @default.
• W1996276518 cites W371386559 @default.
• W1996276518 cites W4245522537 @default.
• W1996276518 doi "https://doi.org/10.1016/j.jaut.2005.06.002" @default.
• W1996276518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16242302" @default.
• W1996276518 hasPublicationYear "2005" @default.
• W1996276518 type Work @default.
• W1996276518 sameAs 1996276518 @default.
• W1996276518 citedByCount "46" @default.
• W1996276518 countsByYear W19962765182012 @default.
• W1996276518 countsByYear W19962765182013 @default.
• W1996276518 countsByYear W19962765182014 @default.
• W1996276518 countsByYear W19962765182015 @default.
• W1996276518 countsByYear W19962765182016 @default.
• W1996276518 countsByYear W19962765182017 @default.
• W1996276518 countsByYear W19962765182019 @default.
• W1996276518 countsByYear W19962765182020 @default.
• W1996276518 countsByYear W19962765182021 @default.
• W1996276518 countsByYear W19962765182022 @default.
• W1996276518 countsByYear W19962765182023 @default.
• W1996276518 crossrefType "journal-article" @default.
• W1996276518 hasAuthorship W1996276518A5047326414 @default.
• W1996276518 hasAuthorship W1996276518A5060130752 @default.
• W1996276518 hasAuthorship W1996276518A5076929039 @default.
• W1996276518 hasAuthorship W1996276518A5089372835 @default.
• W1996276518 hasConcept C12590561 @default.
• W1996276518 hasConcept C159654299 @default.
• W1996276518 hasConcept C203014093 @default.
• W1996276518 hasConcept C2776914184 @default.
• W1996276518 hasConcept C2777077863 @default.
• W1996276518 hasConcept C2777575956 @default.
• W1996276518 hasConcept C2777863537 @default.
• W1996276518 hasConcept C2779075594 @default.
• W1996276518 hasConcept C2780801004 @default.
• W1996276518 hasConcept C2780917455 @default.
• W1996276518 hasConcept C71924100 @default.
• W1996276518 hasConcept C86803240 @default.
• W1996276518 hasConcept C8891405 @default.
• W1996276518 hasConcept C89423630 @default.
• W1996276518 hasConceptScore W1996276518C12590561 @default.
• W1996276518 hasConceptScore W1996276518C159654299 @default.
• W1996276518 hasConceptScore W1996276518C203014093 @default.
• W1996276518 hasConceptScore W1996276518C2776914184 @default.
• W1996276518 hasConceptScore W1996276518C2777077863 @default.
• W1996276518 hasConceptScore W1996276518C2777575956 @default.
• W1996276518 hasConceptScore W1996276518C2777863537 @default.
• W1996276518 hasConceptScore W1996276518C2779075594 @default.
• W1996276518 hasConceptScore W1996276518C2780801004 @default.
• W1996276518 hasConceptScore W1996276518C2780917455 @default.
• W1996276518 hasConceptScore W1996276518C71924100 @default.
• W1996276518 hasConceptScore W1996276518C86803240 @default.
• W1996276518 hasConceptScore W1996276518C8891405 @default.
• W1996276518 hasConceptScore W1996276518C89423630 @default.

• next