Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996279435> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1996279435 endingPage "354" @default.
- W1996279435 startingPage "345" @default.
- W1996279435 abstract "Lymphoid cell lines were established which stably carry the Epstein-Barr viral (EBV) BZLF1 gene on an extrachromosomal plasmid. These lines, which spontaneously synthesize the BZLF1 gene product, ZEBRA, were examined for expression of EBV genes which were activated by ZEBRA. Cell lines which acquired oriP plasmids without BZLF1 served as controls. The extent of activation differed among derivatives of four cell lines. X50-7 cells, which harbor a standard latent EBV, could be induced by ZEBRA to produce transforming virus; a cellular subclone of this line was induced to express EBV late antigens but did not release transforming virus. In two other cell lines, Raji and ER, ZEBRA activated only a group of early antigens. Using immunofluorescence and immunoblotting with monoclonal antibodies and Northern analysis five EBV early genes were shown to be induced in cells stably transformed by oriP/BZLF1 plasmids. ZEBRA itself was activated; thus BZLF1 is autostimulatory. Four other activated genes were components of the diffuse (EA-D) and restricted (EA-R) early antigens (BMRF1, BMLF1, BHRF1, and BORF2). Stable cell lines with extrachromosomal BZLF1 expression vectors will ultimately be useful in a variety of experiments designed to study regulation of this gene, to analyze the effects of mutations on ZEBRA protein function, and to define the full spectrum of viral and cellular genes which are activated by and interact with the ZEBRA protein." @default.
- W1996279435 created "2016-06-24" @default.
- W1996279435 creator A5005174262 @default.
- W1996279435 creator A5006518992 @default.
- W1996279435 creator A5075387122 @default.
- W1996279435 creator A5088010453 @default.
- W1996279435 date "1990-10-01" @default.
- W1996279435 modified "2023-10-15" @default.
- W1996279435 title "Differences in the extent of activation of Epstein-Barr virus replicative gene expression among four nonproducer cell lines stably transformed by OriP/BZLF1 plasmids" @default.
- W1996279435 cites W1487534034 @default.
- W1996279435 cites W1508353819 @default.
- W1996279435 cites W1701172919 @default.
- W1996279435 cites W1755591780 @default.
- W1996279435 cites W1768619516 @default.
- W1996279435 cites W1783659237 @default.
- W1996279435 cites W1804165007 @default.
- W1996279435 cites W1823218897 @default.
- W1996279435 cites W1841083068 @default.
- W1996279435 cites W1845562891 @default.
- W1996279435 cites W1885323688 @default.
- W1996279435 cites W1910426815 @default.
- W1996279435 cites W1930835920 @default.
- W1996279435 cites W1977363649 @default.
- W1996279435 cites W1980464074 @default.
- W1996279435 cites W2015086018 @default.
- W1996279435 cites W2015221134 @default.
- W1996279435 cites W2034617080 @default.
- W1996279435 cites W2071538807 @default.
- W1996279435 cites W2123711411 @default.
- W1996279435 cites W2152827395 @default.
- W1996279435 cites W2164313428 @default.
- W1996279435 cites W2167835886 @default.
- W1996279435 cites W229719265 @default.
- W1996279435 cites W2298027515 @default.
- W1996279435 doi "https://doi.org/10.1016/0042-6822(90)90331-k" @default.
- W1996279435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2171186" @default.
- W1996279435 hasPublicationYear "1990" @default.
- W1996279435 type Work @default.
- W1996279435 sameAs 1996279435 @default.
- W1996279435 citedByCount "25" @default.
- W1996279435 countsByYear W19962794352021 @default.
- W1996279435 crossrefType "journal-article" @default.
- W1996279435 hasAuthorship W1996279435A5005174262 @default.
- W1996279435 hasAuthorship W1996279435A5006518992 @default.
- W1996279435 hasAuthorship W1996279435A5075387122 @default.
- W1996279435 hasAuthorship W1996279435A5088010453 @default.
- W1996279435 hasBestOaLocation W19962794351 @default.
- W1996279435 hasConcept C104317684 @default.
- W1996279435 hasConcept C153911025 @default.
- W1996279435 hasConcept C159047783 @default.
- W1996279435 hasConcept C182615771 @default.
- W1996279435 hasConcept C22744801 @default.
- W1996279435 hasConcept C2522874641 @default.
- W1996279435 hasConcept C2776409557 @default.
- W1996279435 hasConcept C2780727368 @default.
- W1996279435 hasConcept C2781295983 @default.
- W1996279435 hasConcept C2781375147 @default.
- W1996279435 hasConcept C54355233 @default.
- W1996279435 hasConcept C81885089 @default.
- W1996279435 hasConcept C86803240 @default.
- W1996279435 hasConceptScore W1996279435C104317684 @default.
- W1996279435 hasConceptScore W1996279435C153911025 @default.
- W1996279435 hasConceptScore W1996279435C159047783 @default.
- W1996279435 hasConceptScore W1996279435C182615771 @default.
- W1996279435 hasConceptScore W1996279435C22744801 @default.
- W1996279435 hasConceptScore W1996279435C2522874641 @default.
- W1996279435 hasConceptScore W1996279435C2776409557 @default.
- W1996279435 hasConceptScore W1996279435C2780727368 @default.
- W1996279435 hasConceptScore W1996279435C2781295983 @default.
- W1996279435 hasConceptScore W1996279435C2781375147 @default.
- W1996279435 hasConceptScore W1996279435C54355233 @default.
- W1996279435 hasConceptScore W1996279435C81885089 @default.
- W1996279435 hasConceptScore W1996279435C86803240 @default.
- W1996279435 hasFunder F4320306095 @default.
- W1996279435 hasFunder F4320332161 @default.
- W1996279435 hasIssue "2" @default.
- W1996279435 hasLocation W19962794351 @default.
- W1996279435 hasLocation W19962794352 @default.
- W1996279435 hasOpenAccess W1996279435 @default.
- W1996279435 hasPrimaryLocation W19962794351 @default.
- W1996279435 hasRelatedWork W1488560699 @default.
- W1996279435 hasRelatedWork W2049586015 @default.
- W1996279435 hasRelatedWork W2119658998 @default.
- W1996279435 hasRelatedWork W2121615812 @default.
- W1996279435 hasRelatedWork W2312663708 @default.
- W1996279435 hasRelatedWork W2411664980 @default.
- W1996279435 hasRelatedWork W2767420145 @default.
- W1996279435 hasRelatedWork W3175832157 @default.
- W1996279435 hasRelatedWork W4237252206 @default.
- W1996279435 hasRelatedWork W4282936219 @default.
- W1996279435 hasVolume "178" @default.
- W1996279435 isParatext "false" @default.
- W1996279435 isRetracted "false" @default.
- W1996279435 magId "1996279435" @default.
- W1996279435 workType "article" @default.