FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996285410> ?p ?o ?g. }

• W1996285410 endingPage "124" @default.
• W1996285410 startingPage "116" @default.
• W1996285410 abstract "Leucine-rich repeat kinase 2 (LRRK2) is a recently identified gene that, when mutated at specific locations, results in the onset of parkinsonian symptoms with clinical features indistinguishable from idiopathic Parkinson's disease. Based on structural and domain analysis, LRRK2 is predicted to function as a stress-responsive protein scaffold mediating the regulation of mitogen activating protein kinase (MAPK) pathways. Consistent with this notion, our results supported the notion that expression of wild-type LRRK2 but not Y1699C or G2019S mutants enhanced the tolerance of HEK293 and SH-SY5Y cells towards H(2)O(2)-induced oxidative stress. This increase in stress tolerance was dependent on the presence of the kinase domain of the LRRK2 gene and manifested through the activation of the ERK pathway. Collectively, our results indicated that cells expressing LRRK2 mutants suffer a loss of protection normally derived from wild-type LRRK2, making them more vulnerable to oxidative stress." @default.
• W1996285410 created "2016-06-24" @default.
• W1996285410 creator A5000540211 @default.
• W1996285410 creator A5043163138 @default.
• W1996285410 creator A5043868957 @default.
• W1996285410 creator A5058592707 @default.
• W1996285410 date "2008-10-01" @default.
• W1996285410 modified "2023-10-01" @default.
• W1996285410 title "Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway" @default.
• W1996285410 cites W1757845542 @default.
• W1996285410 cites W1971064755 @default.
• W1996285410 cites W1973227020 @default.
• W1996285410 cites W1978728682 @default.
• W1996285410 cites W1981809263 @default.
• W1996285410 cites W1992365739 @default.
• W1996285410 cites W2000030815 @default.
• W1996285410 cites W2006875797 @default.
• W1996285410 cites W2031345305 @default.
• W1996285410 cites W2034247990 @default.
• W1996285410 cites W2035609698 @default.
• W1996285410 cites W2040123229 @default.
• W1996285410 cites W2045512818 @default.
• W1996285410 cites W2047604959 @default.
• W1996285410 cites W2054324553 @default.
• W1996285410 cites W2057630288 @default.
• W1996285410 cites W2060060231 @default.
• W1996285410 cites W2063607711 @default.
• W1996285410 cites W2095169768 @default.
• W1996285410 cites W2100894616 @default.
• W1996285410 cites W2121955382 @default.
• W1996285410 cites W2127647191 @default.
• W1996285410 cites W2129625926 @default.
• W1996285410 cites W2136216054 @default.
• W1996285410 cites W2138315303 @default.
• W1996285410 cites W2154757569 @default.
• W1996285410 cites W4254570323 @default.
• W1996285410 doi "https://doi.org/10.1016/j.nbd.2008.06.016" @default.
• W1996285410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2580823" @default.
• W1996285410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18675914" @default.
• W1996285410 hasPublicationYear "2008" @default.
• W1996285410 type Work @default.
• W1996285410 sameAs 1996285410 @default.
• W1996285410 citedByCount "88" @default.
• W1996285410 countsByYear W19962854102012 @default.
• W1996285410 countsByYear W19962854102013 @default.
• W1996285410 countsByYear W19962854102014 @default.
• W1996285410 countsByYear W19962854102015 @default.
• W1996285410 countsByYear W19962854102016 @default.
• W1996285410 countsByYear W19962854102017 @default.
• W1996285410 countsByYear W19962854102018 @default.
• W1996285410 countsByYear W19962854102019 @default.
• W1996285410 countsByYear W19962854102020 @default.
• W1996285410 countsByYear W19962854102021 @default.
• W1996285410 countsByYear W19962854102022 @default.
• W1996285410 countsByYear W19962854102023 @default.
• W1996285410 crossrefType "journal-article" @default.
• W1996285410 hasAuthorship W1996285410A5000540211 @default.
• W1996285410 hasAuthorship W1996285410A5043163138 @default.
• W1996285410 hasAuthorship W1996285410A5043868957 @default.
• W1996285410 hasAuthorship W1996285410A5058592707 @default.
• W1996285410 hasBestOaLocation W19962854102 @default.
• W1996285410 hasConcept C104317684 @default.
• W1996285410 hasConcept C137361374 @default.
• W1996285410 hasConcept C143065580 @default.
• W1996285410 hasConcept C174510640 @default.
• W1996285410 hasConcept C184235292 @default.
• W1996285410 hasConcept C185592680 @default.
• W1996285410 hasConcept C207583985 @default.
• W1996285410 hasConcept C2776151105 @default.
• W1996285410 hasConcept C2780427247 @default.
• W1996285410 hasConcept C32619005 @default.
• W1996285410 hasConcept C501734568 @default.
• W1996285410 hasConcept C53645450 @default.
• W1996285410 hasConcept C54355233 @default.
• W1996285410 hasConcept C55493867 @default.
• W1996285410 hasConcept C57074206 @default.
• W1996285410 hasConcept C62478195 @default.
• W1996285410 hasConcept C86803240 @default.
• W1996285410 hasConcept C95444343 @default.
• W1996285410 hasConcept C97029542 @default.
• W1996285410 hasConcept C99545290 @default.
• W1996285410 hasConceptScore W1996285410C104317684 @default.
• W1996285410 hasConceptScore W1996285410C137361374 @default.
• W1996285410 hasConceptScore W1996285410C143065580 @default.
• W1996285410 hasConceptScore W1996285410C174510640 @default.
• W1996285410 hasConceptScore W1996285410C184235292 @default.
• W1996285410 hasConceptScore W1996285410C185592680 @default.
• W1996285410 hasConceptScore W1996285410C207583985 @default.
• W1996285410 hasConceptScore W1996285410C2776151105 @default.
• W1996285410 hasConceptScore W1996285410C2780427247 @default.
• W1996285410 hasConceptScore W1996285410C32619005 @default.
• W1996285410 hasConceptScore W1996285410C501734568 @default.
• W1996285410 hasConceptScore W1996285410C53645450 @default.
• W1996285410 hasConceptScore W1996285410C54355233 @default.
• W1996285410 hasConceptScore W1996285410C55493867 @default.
• W1996285410 hasConceptScore W1996285410C57074206 @default.
• W1996285410 hasConceptScore W1996285410C62478195 @default.
• W1996285410 hasConceptScore W1996285410C86803240 @default.

• next