Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996294290> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1996294290 endingPage "30" @default.
- W1996294290 startingPage "19" @default.
- W1996294290 abstract "Intravenous administration of dihydralazine, phentolamine, or prazosin (0.3 mg/kg) produced similar decreases in blood pressure in pentobarbital-anesthetized spontaneously hypertensive rats (SHR), as well as in pithed SHR whose blood pressure had been raised by an i.v. infusion of cirazoline or by electrical spinal cord stimulation. However, only dihydralazine produced vasodilatation in pithed SHR with blood pressure unaltered or elevated by an i.v. infusion of vasopressin, and this effect was not modified by atropine, propranolol, or promethazine. In pithed SHR the pressor responses to norepinephrine or electrical stimulation of the spinal cord were less inhibited after phentolamine than after prazosin (0.3 mg/kg, i.v.). Furthermore, only phentolamine induced a significantly smaller blockade of responses to electrical spinal cord stimulation than to exogenous norepinephrine. The 5-hydroxytryptamine pressor responses were significantly reduced by both i.v. methysergide (5 μg/kg) and phentolamine (1.0 mg/kg), but were unchanged or slightly enhanced by prazosin (0.3 and 1.0 mg/kg). In pithed normotensive rats with a sustained sympathetic tachycardia produced by thoracic spinal cord stimulation, i.v. clonidine increased blood pressure and lowered heart rate. Intravenous phentolamine (1.0 mg/kg) competitively antagonized both effects of clonidine, whereas prazosin (1.0 and 5.0 mg/kg) or dihydralazine (1.0 mg/kg) affected only the clonidine pressor responses. These results indicate that in the rat prazosin inhibits vascular postsynaptic α-adrenoceptors and lacks the direct vascular smooth muscle relaxant activity possessed by dihydralazine. Prazosin differed from phentolamine in that it inhibited the pressor responses to endogenous and exogenous norepinephrine similarly and interfered neither with cardiac presynaptic α-adrenoceptors nor with vascular postsynaptic 5-hydroxytryptamine receptors." @default.
- W1996294290 created "2016-06-24" @default.
- W1996294290 creator A5004331381 @default.
- W1996294290 creator A5048743169 @default.
- W1996294290 creator A5077822501 @default.
- W1996294290 date "1979-01-01" @default.
- W1996294290 modified "2023-10-16" @default.
- W1996294290 title "Comparison of Cardiovascular Actions of Dihydralazine, Phentolamine, and Prazosin in Spontaneously Hypertensive Rats" @default.
- W1996294290 doi "https://doi.org/10.1097/00005344-197901000-00003" @default.
- W1996294290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/94378" @default.
- W1996294290 hasPublicationYear "1979" @default.
- W1996294290 type Work @default.
- W1996294290 sameAs 1996294290 @default.
- W1996294290 citedByCount "19" @default.
- W1996294290 countsByYear W19962942902016 @default.
- W1996294290 crossrefType "journal-article" @default.
- W1996294290 hasAuthorship W1996294290A5004331381 @default.
- W1996294290 hasAuthorship W1996294290A5048743169 @default.
- W1996294290 hasAuthorship W1996294290A5077822501 @default.
- W1996294290 hasBestOaLocation W19962942901 @default.
- W1996294290 hasConcept C126322002 @default.
- W1996294290 hasConcept C134018914 @default.
- W1996294290 hasConcept C170493617 @default.
- W1996294290 hasConcept C185592680 @default.
- W1996294290 hasConcept C2776885963 @default.
- W1996294290 hasConcept C2778151854 @default.
- W1996294290 hasConcept C2778399450 @default.
- W1996294290 hasConcept C2778514916 @default.
- W1996294290 hasConcept C2780253649 @default.
- W1996294290 hasConcept C2780648677 @default.
- W1996294290 hasConcept C42219234 @default.
- W1996294290 hasConcept C513476851 @default.
- W1996294290 hasConcept C71924100 @default.
- W1996294290 hasConcept C84393581 @default.
- W1996294290 hasConceptScore W1996294290C126322002 @default.
- W1996294290 hasConceptScore W1996294290C134018914 @default.
- W1996294290 hasConceptScore W1996294290C170493617 @default.
- W1996294290 hasConceptScore W1996294290C185592680 @default.
- W1996294290 hasConceptScore W1996294290C2776885963 @default.
- W1996294290 hasConceptScore W1996294290C2778151854 @default.
- W1996294290 hasConceptScore W1996294290C2778399450 @default.
- W1996294290 hasConceptScore W1996294290C2778514916 @default.
- W1996294290 hasConceptScore W1996294290C2780253649 @default.
- W1996294290 hasConceptScore W1996294290C2780648677 @default.
- W1996294290 hasConceptScore W1996294290C42219234 @default.
- W1996294290 hasConceptScore W1996294290C513476851 @default.
- W1996294290 hasConceptScore W1996294290C71924100 @default.
- W1996294290 hasConceptScore W1996294290C84393581 @default.
- W1996294290 hasIssue "1" @default.
- W1996294290 hasLocation W19962942901 @default.
- W1996294290 hasLocation W19962942902 @default.
- W1996294290 hasLocation W19962942903 @default.
- W1996294290 hasOpenAccess W1996294290 @default.
- W1996294290 hasPrimaryLocation W19962942901 @default.
- W1996294290 hasRelatedWork W1980319488 @default.
- W1996294290 hasRelatedWork W1983321239 @default.
- W1996294290 hasRelatedWork W2011727899 @default.
- W1996294290 hasRelatedWork W2055714395 @default.
- W1996294290 hasRelatedWork W2091022983 @default.
- W1996294290 hasRelatedWork W2110889457 @default.
- W1996294290 hasRelatedWork W2204934149 @default.
- W1996294290 hasRelatedWork W2259417325 @default.
- W1996294290 hasRelatedWork W2415068333 @default.
- W1996294290 hasRelatedWork W2748952813 @default.
- W1996294290 hasVolume "1" @default.
- W1996294290 isParatext "false" @default.
- W1996294290 isRetracted "false" @default.
- W1996294290 magId "1996294290" @default.
- W1996294290 workType "article" @default.