Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996295012> ?p ?o ?g. }
- W1996295012 endingPage "e77972" @default.
- W1996295012 startingPage "e77972" @default.
- W1996295012 abstract "HIV-1 Tat protein plays various roles in virus proliferation and in the regulation of numerous host cell functions. Accumulating evidence suggests that HIV-1 Tat also plays an important role in HIV-associated neurocognitive disorders (HAND) by disrupting intracellular communication. Amyloid beta (Aβ) is generated from amyloid precursor protein (APP) and accumulates in the senile plaques of Alzheimer's disease patients. This study demonstrates that Tat interacts with APP both in vitro and in vivo, and increases the level of Aβ42 by recruiting APP into lipid rafts. Co-localization of Tat with APP in the cytosol was observed in U-87 MG cells that expressed high levels of Tat, and redistribution of APP into lipid rafts, a site of increased β- and γ-secretase activity, was demonstrated by discontinuous sucrose density gradient ultracentrifugation in the presence of Tat. Furthermore, Tat enhanced the cleavage of APP by β-secretase in vitro, resulting in 5.5-fold higher levels of Aβ42. This was consistent with increased levels of β-C-terminal fragment (β-CTF) and reduced levels of α-CTF. Moreover, stereotaxic injection of a lentiviral Tat expression construct into the hippocampus of APP/presenilin-1 (PS1) transgenic mice resulted in increased Tat-mediated production and processing of Aβ in vivo. Increased levels of Aβ42, as well as an increase in the number and size of Aβ plaques, were observed in the hippocampus following injection of Tat virus compared with mock virus. These results suggest that HIV-1 Tat may contribute to HAND by interacting with and modifying APP processing, thereby increasing Aβ production." @default.
- W1996295012 created "2016-06-24" @default.
- W1996295012 creator A5013391365 @default.
- W1996295012 creator A5041792310 @default.
- W1996295012 creator A5054535831 @default.
- W1996295012 date "2013-11-29" @default.
- W1996295012 modified "2023-10-17" @default.
- W1996295012 title "HIV-1 Tat Interacts with and Regulates the Localization and Processing of Amyloid Precursor Protein" @default.
- W1996295012 cites W1502820594 @default.
- W1996295012 cites W1510277739 @default.
- W1996295012 cites W1574959285 @default.
- W1996295012 cites W1593508376 @default.
- W1996295012 cites W1655404681 @default.
- W1996295012 cites W1659719610 @default.
- W1996295012 cites W1975567099 @default.
- W1996295012 cites W1976981142 @default.
- W1996295012 cites W1981552723 @default.
- W1996295012 cites W1982004402 @default.
- W1996295012 cites W1983734969 @default.
- W1996295012 cites W1983740174 @default.
- W1996295012 cites W1987309942 @default.
- W1996295012 cites W1991662120 @default.
- W1996295012 cites W1991854031 @default.
- W1996295012 cites W2001088431 @default.
- W1996295012 cites W2003890494 @default.
- W1996295012 cites W2006351633 @default.
- W1996295012 cites W2009761723 @default.
- W1996295012 cites W2011895156 @default.
- W1996295012 cites W2015600776 @default.
- W1996295012 cites W2022973538 @default.
- W1996295012 cites W2026053103 @default.
- W1996295012 cites W2026675906 @default.
- W1996295012 cites W2027580727 @default.
- W1996295012 cites W2028639177 @default.
- W1996295012 cites W2031565865 @default.
- W1996295012 cites W2033154907 @default.
- W1996295012 cites W2039864274 @default.
- W1996295012 cites W2044838385 @default.
- W1996295012 cites W2046468113 @default.
- W1996295012 cites W2047248575 @default.
- W1996295012 cites W2051515210 @default.
- W1996295012 cites W2056473993 @default.
- W1996295012 cites W2057973294 @default.
- W1996295012 cites W2058071886 @default.
- W1996295012 cites W2058881577 @default.
- W1996295012 cites W2061573451 @default.
- W1996295012 cites W2061735639 @default.
- W1996295012 cites W2064844843 @default.
- W1996295012 cites W2077403587 @default.
- W1996295012 cites W2077459912 @default.
- W1996295012 cites W2081881251 @default.
- W1996295012 cites W2087158265 @default.
- W1996295012 cites W2094871029 @default.
- W1996295012 cites W2095083924 @default.
- W1996295012 cites W2096740761 @default.
- W1996295012 cites W2099667797 @default.
- W1996295012 cites W2100222947 @default.
- W1996295012 cites W2100898704 @default.
- W1996295012 cites W2114642696 @default.
- W1996295012 cites W2119487442 @default.
- W1996295012 cites W2120658132 @default.
- W1996295012 cites W2130512651 @default.
- W1996295012 cites W2140347837 @default.
- W1996295012 cites W2147310858 @default.
- W1996295012 cites W2147958725 @default.
- W1996295012 cites W2148595561 @default.
- W1996295012 cites W2153266207 @default.
- W1996295012 cites W2153325989 @default.
- W1996295012 cites W2160524771 @default.
- W1996295012 cites W2160557659 @default.
- W1996295012 cites W2163001678 @default.
- W1996295012 cites W2169555689 @default.
- W1996295012 cites W2170644095 @default.
- W1996295012 cites W2386517867 @default.
- W1996295012 cites W4248025115 @default.
- W1996295012 doi "https://doi.org/10.1371/journal.pone.0077972" @default.
- W1996295012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3843664" @default.
- W1996295012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24312169" @default.
- W1996295012 hasPublicationYear "2013" @default.
- W1996295012 type Work @default.
- W1996295012 sameAs 1996295012 @default.
- W1996295012 citedByCount "57" @default.
- W1996295012 countsByYear W19962950122014 @default.
- W1996295012 countsByYear W19962950122015 @default.
- W1996295012 countsByYear W19962950122016 @default.
- W1996295012 countsByYear W19962950122017 @default.
- W1996295012 countsByYear W19962950122018 @default.
- W1996295012 countsByYear W19962950122019 @default.
- W1996295012 countsByYear W19962950122020 @default.
- W1996295012 countsByYear W19962950122021 @default.
- W1996295012 countsByYear W19962950122022 @default.
- W1996295012 countsByYear W19962950122023 @default.
- W1996295012 crossrefType "journal-article" @default.
- W1996295012 hasAuthorship W1996295012A5013391365 @default.
- W1996295012 hasAuthorship W1996295012A5041792310 @default.
- W1996295012 hasAuthorship W1996295012A5054535831 @default.
- W1996295012 hasBestOaLocation W19962950121 @default.
- W1996295012 hasConcept C102230213 @default.