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• W1996298509 abstract "Opiate withdrawal has been associated with up-regulation of α2-adrenoceptors (mainly the α2A-subtype) in brain. The modulation of these inhibitory receptors regulating norepinephrine release appears to be a relevant mechanism by which the opiate abstinence syndrome might be counteracted. The aim of this study was to investigate possible changes in α2a-adrenoceptor gene expression as the molecular mechanism underlying the opiate withdrawal-induced up-regulation of α2A-adrenoceptors. In morphine-dependent rats (10–100 mg/kg for 5 days), naloxone (2 mg/kg)-precipitated withdrawal induced a rapid (2 h) and marked up-regulation (111%, P < 0.001) in the expression of α2a-adrenoceptor mRNA (Northern and dot-blot analyses) in the cerebral cortex. Acute and chronic morphine treatments did not alter significantly the expression of cortical α2a-adrenoceptor mRNA. The results indicate that the opiate abstinence syndrome is associated with a transcriptional activation of the α2a-adrenoceptors mRNA which can explain the up-regulation of brain α2A-adrenoceptors during opiate withdrawal." @default.
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• W1996298509 date "1997-04-01" @default.
• W1996298509 modified "2023-10-18" @default.
• W1996298509 title "Naloxone-precipitated withdrawal in morphine-dependent rats increases the expression of α2a-adrenoceptor mRNA in brain" @default.
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• W1996298509 doi "https://doi.org/10.1016/s0169-328x(96)00307-5" @default.
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