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- W1996299724 endingPage "495" @default.
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- W1996299724 abstract "Genome-wide association studies have identified many variants that each affects multiple traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, suggesting that pleiotropic effects on human complex traits may be widespread. However, systematic detection of such effects is challenging and requires new methodologies and frameworks for interpreting cross-phenotype results. In this Review, we discuss the evidence for pleiotropy in contemporary genetic mapping studies, new and established analytical approaches to identifying pleiotropic effects, sources of spurious cross-phenotype effects and study design considerations. We also outline the molecular and clinical implications of such findings and discuss future directions of research." @default.
- W1996299724 created "2016-06-24" @default.
- W1996299724 creator A5028238588 @default.
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- W1996299724 creator A5041227452 @default.
- W1996299724 creator A5044998046 @default.
- W1996299724 creator A5051460895 @default.
- W1996299724 date "2013-06-11" @default.
- W1996299724 modified "2023-10-16" @default.
- W1996299724 title "Pleiotropy in complex traits: challenges and strategies" @default.
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