FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996302313> ?p ?o ?g. }

• W1996302313 endingPage "716" @default.
• W1996302313 startingPage "712" @default.
• W1996302313 abstract "Nicotine-associated paraphernalia such as cigarettes and ashtrays are potent smoking relapse triggers. In addition to these discrete cues, environmental contexts previously associated with smoking elicit strong cigarette craving, indicating that contextual stimuli also contribute to high smoking relapse rates. Nonetheless, little is known about the precise role of these stimuli in smoking relapse and the neuropharmacological mechanisms implicated herein. To address this issue, we determined whether re-exposure to the nicotine self-administration context after long-term extinction reinstates nicotine seeking behavior in rats. Further, we examined the effects of SR141716A (Rimonabant), a selective cannabinoid CB1 receptor antagonist which has been shown to attenuate cue-induced relapse to nicotine seeking, on context-induced reinstatement of nicotine seeking. Rats were trained to self-administer nicotine intravenously (30 μg/kg/infusion). Nicotine infusions were paired with an audiovisual compound stimulus. Subsequently, nose poking behavior was extinguished in the presence of this discrete cue in a context different from the self-administration context. Hereafter, rats were injected with 0, 1, or 3 mg/kg Rimonabant (i.p.) prior to re-exposure to either the self-administration or the extinction context. Re-exposure to the self-administration context, but not to the extinction context robustly reinstated responding for the discrete nicotine cues, an effect that was dose-dependently attenuated by Rimonabant. This is the first demonstration of contextual renewal of nicotine seeking in rodents after prolonged withdrawal. Further, our results indicate that the endocannabinoid system is involved in context-induced relapse to nicotine seeking, and as such these data provide further evidence for the use of CB1 antagonists in smoking cessation." @default.
• W1996302313 created "2016-06-24" @default.
• W1996302313 creator A5010675782 @default.
• W1996302313 creator A5038668787 @default.
• W1996302313 creator A5061161310 @default.
• W1996302313 creator A5061197527 @default.
• W1996302313 creator A5089478783 @default.
• W1996302313 date "2008-10-01" @default.
• W1996302313 modified "2023-10-02" @default.
• W1996302313 title "Contextual renewal of nicotine seeking in rats and its suppression by the cannabinoid-1 receptor antagonist Rimonabant (SR141716A)" @default.
• W1996302313 cites W1605427252 @default.
• W1996302313 cites W1836729582 @default.
• W1996302313 cites W1914672590 @default.
• W1996302313 cites W1950636139 @default.
• W1996302313 cites W1964739293 @default.
• W1996302313 cites W1969949247 @default.
• W1996302313 cites W1970885260 @default.
• W1996302313 cites W1971422825 @default.
• W1996302313 cites W1972440662 @default.
• W1996302313 cites W1976328383 @default.
• W1996302313 cites W1981461770 @default.
• W1996302313 cites W1984445918 @default.
• W1996302313 cites W1992710392 @default.
• W1996302313 cites W1997189506 @default.
• W1996302313 cites W1999038462 @default.
• W1996302313 cites W2002459043 @default.
• W1996302313 cites W2013262372 @default.
• W1996302313 cites W2018858170 @default.
• W1996302313 cites W2030129723 @default.
• W1996302313 cites W2032488758 @default.
• W1996302313 cites W2041639711 @default.
• W1996302313 cites W2054836161 @default.
• W1996302313 cites W2056711311 @default.
• W1996302313 cites W2057536623 @default.
• W1996302313 cites W2060161739 @default.
• W1996302313 cites W2060694966 @default.
• W1996302313 cites W2070212982 @default.
• W1996302313 cites W2072696576 @default.
• W1996302313 cites W2072724153 @default.
• W1996302313 cites W2074335645 @default.
• W1996302313 cites W2075644153 @default.
• W1996302313 cites W2090618383 @default.
• W1996302313 cites W2103263170 @default.
• W1996302313 cites W2104024362 @default.
• W1996302313 cites W2104094850 @default.
• W1996302313 cites W2108489388 @default.
• W1996302313 cites W2114331575 @default.
• W1996302313 cites W2117879547 @default.
• W1996302313 cites W2130347768 @default.
• W1996302313 cites W2145465887 @default.
• W1996302313 cites W2158753468 @default.
• W1996302313 cites W2159655610 @default.
• W1996302313 cites W2171448530 @default.
• W1996302313 doi "https://doi.org/10.1016/j.neuropharm.2008.06.003" @default.
• W1996302313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18588903" @default.
• W1996302313 hasPublicationYear "2008" @default.
• W1996302313 type Work @default.
• W1996302313 sameAs 1996302313 @default.
• W1996302313 citedByCount "74" @default.
• W1996302313 countsByYear W19963023132012 @default.
• W1996302313 countsByYear W19963023132013 @default.
• W1996302313 countsByYear W19963023132014 @default.
• W1996302313 countsByYear W19963023132015 @default.
• W1996302313 countsByYear W19963023132016 @default.
• W1996302313 countsByYear W19963023132017 @default.
• W1996302313 countsByYear W19963023132018 @default.
• W1996302313 countsByYear W19963023132019 @default.
• W1996302313 countsByYear W19963023132020 @default.
• W1996302313 countsByYear W19963023132021 @default.
• W1996302313 countsByYear W19963023132022 @default.
• W1996302313 countsByYear W19963023132023 @default.
• W1996302313 crossrefType "journal-article" @default.
• W1996302313 hasAuthorship W1996302313A5010675782 @default.
• W1996302313 hasAuthorship W1996302313A5038668787 @default.
• W1996302313 hasAuthorship W1996302313A5061161310 @default.
• W1996302313 hasAuthorship W1996302313A5061197527 @default.
• W1996302313 hasAuthorship W1996302313A5089478783 @default.
• W1996302313 hasConcept C101991246 @default.
• W1996302313 hasConcept C118552586 @default.
• W1996302313 hasConcept C126322002 @default.
• W1996302313 hasConcept C142724271 @default.
• W1996302313 hasConcept C148001335 @default.
• W1996302313 hasConcept C151730666 @default.
• W1996302313 hasConcept C15744967 @default.
• W1996302313 hasConcept C169760540 @default.
• W1996302313 hasConcept C170493617 @default.
• W1996302313 hasConcept C185592680 @default.
• W1996302313 hasConcept C199289684 @default.
• W1996302313 hasConcept C2776433454 @default.
• W1996302313 hasConcept C2776880047 @default.
• W1996302313 hasConcept C2776885963 @default.
• W1996302313 hasConcept C2777843972 @default.
• W1996302313 hasConcept C2778555786 @default.
• W1996302313 hasConcept C2778938600 @default.
• W1996302313 hasConcept C2779177420 @default.
• W1996302313 hasConcept C2779343474 @default.
• W1996302313 hasConcept C2779541405 @default.
• W1996302313 hasConcept C2779547902 @default.

• next