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• W1996303419 startingPage "e96" @default.
• W1996303419 abstract "Signaling by the Notch ligands Delta (Dl) and Serrate (Ser) regulates a wide variety of essential cell-fate decisions during animal development. Two distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), have been shown to regulate Dl signaling in Drosophila melanogaster and Danio rerio, respectively. While the neur and mib genes are evolutionarily conserved, their respective roles in the context of a single organism have not yet been examined. We show here that the Drosophila mind bomb (D-mib) gene regulates a subset of Notch signaling events, including wing margin specification, leg segmentation, and vein determination, that are distinct from those events requiring neur activity. D-mib also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting that D-mib regulates Dl signaling. During wing development, expression of D-mib in dorsal cells appears to be necessary and sufficient for wing margin specification, indicating that D-mib also regulates Ser signaling. Moreover, the activity of the D-mib gene is required for the endocytosis of Ser in wing imaginal disc cells. Finally, ectopic expression of neur in D-mib mutant larvae rescues the wing D-mib phenotype, indicating that Neur can compensate for the lack of D-mib activity. We conclude that D-mib and Neur are two structurally distinct proteins that have similar molecular activities but distinct developmental functions in Drosophila." @default.
• W1996303419 created "2016-06-24" @default.
• W1996303419 creator A5029859426 @default.
• W1996303419 creator A5075419033 @default.
• W1996303419 creator A5083574103 @default.
• W1996303419 creator A5088405752 @default.
• W1996303419 date "2005-03-15" @default.
• W1996303419 modified "2023-10-18" @default.
• W1996303419 title "Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila" @default.
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• W1996303419 doi "https://doi.org/10.1371/journal.pbio.0030096" @default.
• W1996303419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1064853" @default.
• W1996303419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15760269" @default.
• W1996303419 hasPublicationYear "2005" @default.
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