Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996304492> ?p ?o ?g. }
- W1996304492 endingPage "4331" @default.
- W1996304492 startingPage "4327" @default.
- W1996304492 abstract "Two uncharged 99mTc-labeled phenylbenzoxazole derivatives were biologically evaluated as potential imaging probes for β-amyloid plaques. The 99mTc and corresponding rhenium complexes were synthesized by coupling monoamine–monoamide dithiol (MAMA) and bis(aminoethanethiol) (BAT) chelating ligand via a pentyloxy spacer to phenylbenzoxazole. The fluorescent rhenium complexes 6 and 9 selectively stainined the β-amyloid plaques on the sections of transgenic mouse, and showed high affinity for Aβ(1–42) aggregates (Ki = 11.1 nM and 14.3 nM, respectively). Autoradiography in vitro indicated that [99mTc]6 clearly labeled β-amyloid plaques on the sections of transgenic mouse. Biodistribution experiments in normal mice revealed that [99mTc]6 displayed moderate initial brain uptake (0.81% ID/g at 2 min), and quickly washed out from the brain (0.25% ID/g at 60 min). The preliminary results indicate that the properties of [99mTc]6 are promising, although additional refinements are needed to improve the ability to cross the blood–brain barrier." @default.
- W1996304492 created "2016-06-24" @default.
- W1996304492 creator A5018784384 @default.
- W1996304492 creator A5031751091 @default.
- W1996304492 creator A5042508244 @default.
- W1996304492 creator A5065966968 @default.
- W1996304492 creator A5070888424 @default.
- W1996304492 creator A5079627298 @default.
- W1996304492 creator A5083614937 @default.
- W1996304492 date "2012-07-01" @default.
- W1996304492 modified "2023-10-02" @default.
- W1996304492 title "Synthesis and biological evaluation of novel technetium-99m labeled phenylbenzoxazole derivatives as potential imaging probes for β-amyloid plaques in brain" @default.
- W1996304492 cites W1969218941 @default.
- W1996304492 cites W1990867963 @default.
- W1996304492 cites W1998335761 @default.
- W1996304492 cites W2012067993 @default.
- W1996304492 cites W2017460707 @default.
- W1996304492 cites W2018648002 @default.
- W1996304492 cites W2024965845 @default.
- W1996304492 cites W2027781655 @default.
- W1996304492 cites W2035146506 @default.
- W1996304492 cites W2036094586 @default.
- W1996304492 cites W2047623666 @default.
- W1996304492 cites W2054089714 @default.
- W1996304492 cites W2055100869 @default.
- W1996304492 cites W2055859393 @default.
- W1996304492 cites W2057421799 @default.
- W1996304492 cites W2060685446 @default.
- W1996304492 cites W2070882985 @default.
- W1996304492 cites W2071121851 @default.
- W1996304492 cites W2084217679 @default.
- W1996304492 cites W2090778626 @default.
- W1996304492 cites W2091379146 @default.
- W1996304492 cites W2096410114 @default.
- W1996304492 cites W2103440561 @default.
- W1996304492 cites W2115735718 @default.
- W1996304492 cites W2118935127 @default.
- W1996304492 cites W2137632876 @default.
- W1996304492 cites W2146446340 @default.
- W1996304492 cites W2151908951 @default.
- W1996304492 cites W2158407564 @default.
- W1996304492 cites W2159789463 @default.
- W1996304492 cites W2167720733 @default.
- W1996304492 cites W2169152986 @default.
- W1996304492 cites W2170644926 @default.
- W1996304492 doi "https://doi.org/10.1016/j.bmcl.2012.05.010" @default.
- W1996304492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22652052" @default.
- W1996304492 hasPublicationYear "2012" @default.
- W1996304492 type Work @default.
- W1996304492 sameAs 1996304492 @default.
- W1996304492 citedByCount "26" @default.
- W1996304492 countsByYear W19963044922013 @default.
- W1996304492 countsByYear W19963044922014 @default.
- W1996304492 countsByYear W19963044922015 @default.
- W1996304492 countsByYear W19963044922016 @default.
- W1996304492 countsByYear W19963044922017 @default.
- W1996304492 countsByYear W19963044922018 @default.
- W1996304492 countsByYear W19963044922019 @default.
- W1996304492 countsByYear W19963044922020 @default.
- W1996304492 countsByYear W19963044922022 @default.
- W1996304492 countsByYear W19963044922023 @default.
- W1996304492 crossrefType "journal-article" @default.
- W1996304492 hasAuthorship W1996304492A5018784384 @default.
- W1996304492 hasAuthorship W1996304492A5031751091 @default.
- W1996304492 hasAuthorship W1996304492A5042508244 @default.
- W1996304492 hasAuthorship W1996304492A5065966968 @default.
- W1996304492 hasAuthorship W1996304492A5070888424 @default.
- W1996304492 hasAuthorship W1996304492A5079627298 @default.
- W1996304492 hasAuthorship W1996304492A5083614937 @default.
- W1996304492 hasConcept C102230213 @default.
- W1996304492 hasConcept C104317684 @default.
- W1996304492 hasConcept C116569031 @default.
- W1996304492 hasConcept C121332964 @default.
- W1996304492 hasConcept C13965031 @default.
- W1996304492 hasConcept C141035611 @default.
- W1996304492 hasConcept C142724271 @default.
- W1996304492 hasConcept C170493617 @default.
- W1996304492 hasConcept C179104552 @default.
- W1996304492 hasConcept C185592680 @default.
- W1996304492 hasConcept C202751555 @default.
- W1996304492 hasConcept C2777633098 @default.
- W1996304492 hasConcept C2777807558 @default.
- W1996304492 hasConcept C2779134260 @default.
- W1996304492 hasConcept C2779902710 @default.
- W1996304492 hasConcept C2984398910 @default.
- W1996304492 hasConcept C2989005 @default.
- W1996304492 hasConcept C3019216857 @default.
- W1996304492 hasConcept C4375535 @default.
- W1996304492 hasConcept C502032728 @default.
- W1996304492 hasConcept C505216180 @default.
- W1996304492 hasConcept C522557706 @default.
- W1996304492 hasConcept C55493867 @default.
- W1996304492 hasConcept C62520636 @default.
- W1996304492 hasConcept C71924100 @default.
- W1996304492 hasConcept C91881484 @default.
- W1996304492 hasConceptScore W1996304492C102230213 @default.
- W1996304492 hasConceptScore W1996304492C104317684 @default.
- W1996304492 hasConceptScore W1996304492C116569031 @default.