FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996310984> ?p ?o ?g. }

• W1996310984 endingPage "e77468" @default.
• W1996310984 startingPage "e77468" @default.
• W1996310984 abstract "Diabetic nephropathy is the most common cause of chronic kidney failure and end-stage renal disease in the Western World. One of the major characteristics of this disease is the excessive accumulation of extracellular matrix (ECM) in the kidney glomeruli. While both environmental and genetic determinants are recognized for their role in the development of diabetic nephropathy, epigenetic factors, such as DNA methylation, long non-coding RNAs, and microRNAs, have also recently been found to underlie some of the biological mechanisms, including ECM accumulation, leading to the disease. We previously found that a long non-coding RNA, the plasmacytoma variant translocation 1 (PVT1), increases plasminogen activator inhibitor 1 (PAI-1) and transforming growth factor beta 1 (TGF-β1) in mesangial cells, the two main contributors to ECM accumulation in the glomeruli under hyperglycemic conditions, as well as fibronectin 1 (FN1), a major ECM component. Here, we report that miR-1207-5p, a PVT1-derived microRNA, is abundantly expressed in kidney cells, and is upregulated by glucose and TGF-β1. We also found that like PVT1, miR-1207-5p increases expression of TGF-β1, PAI-1, and FN1 but in a manner that is independent of its host gene. In addition, regulation of miR-1207-5p expression by glucose and TGFβ1 is independent of PVT1. These results provide evidence supporting important roles for miR-1207-5p and its host gene in the complex pathogenesis of diabetic nephropathy." @default.
• W1996310984 created "2016-06-24" @default.
• W1996310984 creator A5014676781 @default.
• W1996310984 creator A5050749811 @default.
• W1996310984 creator A5077946638 @default.
• W1996310984 creator A5082779886 @default.
• W1996310984 date "2013-10-25" @default.
• W1996310984 modified "2023-10-18" @default.
• W1996310984 title "Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy" @default.
• W1996310984 cites W1968177335 @default.
• W1996310984 cites W1985839640 @default.
• W1996310984 cites W1986782449 @default.
• W1996310984 cites W1999605403 @default.
• W1996310984 cites W2002229667 @default.
• W1996310984 cites W2006966866 @default.
• W1996310984 cites W2007426117 @default.
• W1996310984 cites W2007701028 @default.
• W1996310984 cites W2010240035 @default.
• W1996310984 cites W2010875822 @default.
• W1996310984 cites W2012521900 @default.
• W1996310984 cites W2013721931 @default.
• W1996310984 cites W2014091091 @default.
• W1996310984 cites W2017077598 @default.
• W1996310984 cites W2020989705 @default.
• W1996310984 cites W2021794410 @default.
• W1996310984 cites W2023121345 @default.
• W1996310984 cites W2026570544 @default.
• W1996310984 cites W2028615837 @default.
• W1996310984 cites W2032144024 @default.
• W1996310984 cites W2036075451 @default.
• W1996310984 cites W2038178085 @default.
• W1996310984 cites W2056083834 @default.
• W1996310984 cites W2059073003 @default.
• W1996310984 cites W2062827875 @default.
• W1996310984 cites W2064434715 @default.
• W1996310984 cites W2068348383 @default.
• W1996310984 cites W2079837239 @default.
• W1996310984 cites W2083381199 @default.
• W1996310984 cites W2088325873 @default.
• W1996310984 cites W2102115518 @default.
• W1996310984 cites W2104538787 @default.
• W1996310984 cites W2109795859 @default.
• W1996310984 cites W2110280725 @default.
• W1996310984 cites W2111478784 @default.
• W1996310984 cites W2115111607 @default.
• W1996310984 cites W2116007807 @default.
• W1996310984 cites W2117814548 @default.
• W1996310984 cites W2119729313 @default.
• W1996310984 cites W2122981222 @default.
• W1996310984 cites W2142718844 @default.
• W1996310984 cites W2145931730 @default.
• W1996310984 cites W2146648170 @default.
• W1996310984 cites W2151911276 @default.
• W1996310984 cites W2151916930 @default.
• W1996310984 cites W2156232364 @default.
• W1996310984 cites W2156935689 @default.
• W1996310984 cites W2159932011 @default.
• W1996310984 cites W2160162572 @default.
• W1996310984 cites W2163784004 @default.
• W1996310984 cites W2165463320 @default.
• W1996310984 cites W2168450345 @default.
• W1996310984 cites W2168837864 @default.
• W1996310984 cites W2171230529 @default.
• W1996310984 cites W2329339300 @default.
• W1996310984 cites W4251765607 @default.
• W1996310984 doi "https://doi.org/10.1371/journal.pone.0077468" @default.
• W1996310984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5148166" @default.
• W1996310984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27936176" @default.
• W1996310984 hasPublicationYear "2013" @default.
• W1996310984 type Work @default.
• W1996310984 sameAs 1996310984 @default.
• W1996310984 citedByCount "131" @default.
• W1996310984 countsByYear W19963109842014 @default.
• W1996310984 countsByYear W19963109842015 @default.
• W1996310984 countsByYear W19963109842016 @default.
• W1996310984 countsByYear W19963109842017 @default.
• W1996310984 countsByYear W19963109842018 @default.
• W1996310984 countsByYear W19963109842019 @default.
• W1996310984 countsByYear W19963109842020 @default.
• W1996310984 countsByYear W19963109842021 @default.
• W1996310984 countsByYear W19963109842022 @default.
• W1996310984 countsByYear W19963109842023 @default.
• W1996310984 crossrefType "journal-article" @default.
• W1996310984 hasAuthorship W1996310984A5014676781 @default.
• W1996310984 hasAuthorship W1996310984A5050749811 @default.
• W1996310984 hasAuthorship W1996310984A5077946638 @default.
• W1996310984 hasAuthorship W1996310984A5082779886 @default.
• W1996310984 hasBestOaLocation W19963109841 @default.
• W1996310984 hasConcept C104317684 @default.
• W1996310984 hasConcept C145059251 @default.
• W1996310984 hasConcept C150194340 @default.
• W1996310984 hasConcept C189165786 @default.
• W1996310984 hasConcept C190727270 @default.
• W1996310984 hasConcept C2779922275 @default.
• W1996310984 hasConcept C2780091579 @default.
• W1996310984 hasConcept C41091548 @default.
• W1996310984 hasConcept C502942594 @default.
• W1996310984 hasConcept C54355233 @default.

• next