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- W1996314721 abstract "The human leukocyte antigen (HLA) class I system comprises a highly polymorphic set of molecules that specifically bind and present peptides to cytotoxic T cells. HLA-B*1501 is a prototypical member of the HLA-B62 supertype and only two peptide–HLA-B*1501 structures have been determined. Here, the crystal structure of HLA-B*1501 in complex with a SARS coronavirus-derived nonapeptide (VQQESSFVM) has been determined at high resolution (1.87 Å). The peptide is deeply anchored in the B and F pockets, but with the Glu4 residue pointing away from the floor in the peptide-binding groove, making it available for interactions with a potential T-cell receptor." @default.
- W1996314721 created "2016-06-24" @default.
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- W1996314721 date "2008-05-17" @default.
- W1996314721 modified "2023-10-14" @default.
- W1996314721 title "Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501" @default.
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- W1996314721 doi "https://doi.org/10.1107/s1744309108012396" @default.
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