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• W1996314963 abstract "Background: Long term survivors of allogeneic HSCT (aHSCT) may experience significant psychosocial distress. Although factors predicting increased distress have been reported, the influence of conditioning intensity has not been explored. Purpose: This analysis compares the psychosocial (PS) adjustment of long term survivors who received RIC (n = 43) or MC (n = 77) regimens and examines predictors of PS adjustment and its relationship with health-related quality of life (HRQL). Methods: Cross-sectional data were drawn from an ongoing longitudinal study. Measures included the Psychosocial Adjustment to Illness Scale (PAIS), the Rotterdam Symptom Checklist-physical (RSCL-P) and the Functional Assessment of Cancer Therapy – General (FACT-G). Data were analyzed using descriptive statistics, correlation and regression analyses. Results: Subjects (N = 120) were a median of 62 months from aHSCT (range 34–156), predominantly male (59%), married (63%), and had an ECOG status of 0 (86%). Mean scores for PS adjustment did not differ between the RIC (27.6±2.56) and MC (26.1±1.82) groups (t = 4.93, p = 0.62). Age, gender, marital status, education, employment, transplant conditioning intensity, performance status and physical symptom distress explained 50.5% of the variability in PAIS scores (F = 9.30, p<0.01). Being unmarried (β =−0.169, p = 0.044) and experiencing greater physical symptom distress (β = 0.609, p<0.001) independently predicted poor adjustment. Poor PS adjustment was strongly associated with poor HRQL (r =−0.78, p<0.001). Survivors (n = 29; 24%) with poor adjustment (PAIS T-score ≥62) reported the greatest difficulties with family (immediate and extended) issues, sexual relationships and psychological distress. Conclusion: Understanding the factors that predict poor PS adjustment in survivors of aHSCT guides assessment strategies including approaches to systematically assess and manage distressing symptoms. Studies to develop and test educational and counseling interventions that optimize individual and family functioning, including sexual relationships, in transplant recipients are warranted. Acknowledgment: This research was supported by the Intramural Research Program of the NIH." @default.
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• W1996314963 date "2009-02-01" @default.
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• W1996314963 title "Psychosocial Adjustment in Long Term Survivors of Allogeneic HSCT: A Comparison of Patients Treated with Myeloablative (MC) and Reduced Intensity Conditioning (RIC) Regimens" @default.
• W1996314963 doi "https://doi.org/10.1016/j.bbmt.2008.12.097" @default.
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