Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996319594> ?p ?o ?g. }
- W1996319594 endingPage "920" @default.
- W1996319594 startingPage "914" @default.
- W1996319594 abstract "After the announcement of a worldwide pandemic in June 2009, a single dose of a monovalent pandemic H1N1 2009 influenza A (pH1N1/09) vaccine was advocated for all Australians who were 10 years and older because of excellent immunogenicity trial results for healthy children and adults. Immunocompromised patients have previously been shown to have lower seroconversion rates after routine vaccinations. There is a lack of data concerning the immune response of this patient group after pH1N1/09 vaccination. The aim of this study was to assess the immunogenicity of a pH1N1/09 vaccine in pediatric liver transplant recipients 10 years of age or older. Liver transplant recipients ≥ 10 years were prospectively recruited. All participants were administered a single intramuscular injection of the pH1N1/09 vaccine (15 μg). Serum antibody levels were determined by hemagglutination immediately before and ≥ 6 weeks after vaccination. Clinical and laboratory data (age, time since transplantation, immunosuppression, and lymphocyte counts) were analyzed comparing seroconverters and nonconverters with the Student's t test. A second dose of the vaccine was offered to all those who displayed no seroprotective titers after the first vaccination. Antibody levels were again determined 6 weeks later. Twenty-one of 28 liver transplant patients completed the study. The seroconversion rate was 62% after the first dose and 89.5% after the second dose. At baseline, 7 of 21 patients (33.4%) were already seropositive. Increasing time since transplantation positively correlated with successful seroconversion. In conclusion, a single dose of a pandemic influenza A vaccine does not elicit a reliable immune response in adolescent pediatric liver transplant patients. A second dose of the vaccine is warranted in this group of patients, at least in a pandemic scenario. There is an urgent need to further assess vaccine strategies in this high-risk group." @default.
- W1996319594 created "2016-06-24" @default.
- W1996319594 creator A5021015653 @default.
- W1996319594 creator A5037877031 @default.
- W1996319594 creator A5039638832 @default.
- W1996319594 creator A5053448084 @default.
- W1996319594 creator A5073077638 @default.
- W1996319594 creator A5082073126 @default.
- W1996319594 date "2011-07-22" @default.
- W1996319594 modified "2023-09-27" @default.
- W1996319594 title "Immune response to pandemic H1N1 2009 influenza a vaccination in pediatric liver transplant recipients" @default.
- W1996319594 cites W1504466911 @default.
- W1996319594 cites W1525574348 @default.
- W1996319594 cites W170049182 @default.
- W1996319594 cites W1808739935 @default.
- W1996319594 cites W1979210826 @default.
- W1996319594 cites W1991619792 @default.
- W1996319594 cites W1992424097 @default.
- W1996319594 cites W2003355207 @default.
- W1996319594 cites W2045584501 @default.
- W1996319594 cites W2047219505 @default.
- W1996319594 cites W2054236936 @default.
- W1996319594 cites W2064225495 @default.
- W1996319594 cites W2068368642 @default.
- W1996319594 cites W2088750774 @default.
- W1996319594 cites W2093086005 @default.
- W1996319594 cites W2097636421 @default.
- W1996319594 cites W2101507927 @default.
- W1996319594 cites W2129589474 @default.
- W1996319594 cites W2132922192 @default.
- W1996319594 cites W2135360970 @default.
- W1996319594 cites W2137673012 @default.
- W1996319594 cites W2139400179 @default.
- W1996319594 cites W2144555928 @default.
- W1996319594 cites W2163022262 @default.
- W1996319594 cites W2168302323 @default.
- W1996319594 cites W2322713961 @default.
- W1996319594 cites W2411667492 @default.
- W1996319594 cites W2597609597 @default.
- W1996319594 doi "https://doi.org/10.1002/lt.22283" @default.
- W1996319594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21351241" @default.
- W1996319594 hasPublicationYear "2011" @default.
- W1996319594 type Work @default.
- W1996319594 sameAs 1996319594 @default.
- W1996319594 citedByCount "11" @default.
- W1996319594 countsByYear W19963195942012 @default.
- W1996319594 countsByYear W19963195942013 @default.
- W1996319594 countsByYear W19963195942014 @default.
- W1996319594 countsByYear W19963195942016 @default.
- W1996319594 countsByYear W19963195942017 @default.
- W1996319594 countsByYear W19963195942018 @default.
- W1996319594 countsByYear W19963195942019 @default.
- W1996319594 crossrefType "journal-article" @default.
- W1996319594 hasAuthorship W1996319594A5021015653 @default.
- W1996319594 hasAuthorship W1996319594A5037877031 @default.
- W1996319594 hasAuthorship W1996319594A5039638832 @default.
- W1996319594 hasAuthorship W1996319594A5053448084 @default.
- W1996319594 hasAuthorship W1996319594A5073077638 @default.
- W1996319594 hasAuthorship W1996319594A5082073126 @default.
- W1996319594 hasConcept C126322002 @default.
- W1996319594 hasConcept C159654299 @default.
- W1996319594 hasConcept C203014093 @default.
- W1996319594 hasConcept C22070199 @default.
- W1996319594 hasConcept C22889606 @default.
- W1996319594 hasConcept C2777451964 @default.
- W1996319594 hasConcept C2779134260 @default.
- W1996319594 hasConcept C2780252810 @default.
- W1996319594 hasConcept C2780689484 @default.
- W1996319594 hasConcept C2780868878 @default.
- W1996319594 hasConcept C3008058167 @default.
- W1996319594 hasConcept C32611913 @default.
- W1996319594 hasConcept C524204448 @default.
- W1996319594 hasConcept C71924100 @default.
- W1996319594 hasConcept C8891405 @default.
- W1996319594 hasConcept C89623803 @default.
- W1996319594 hasConceptScore W1996319594C126322002 @default.
- W1996319594 hasConceptScore W1996319594C159654299 @default.
- W1996319594 hasConceptScore W1996319594C203014093 @default.
- W1996319594 hasConceptScore W1996319594C22070199 @default.
- W1996319594 hasConceptScore W1996319594C22889606 @default.
- W1996319594 hasConceptScore W1996319594C2777451964 @default.
- W1996319594 hasConceptScore W1996319594C2779134260 @default.
- W1996319594 hasConceptScore W1996319594C2780252810 @default.
- W1996319594 hasConceptScore W1996319594C2780689484 @default.
- W1996319594 hasConceptScore W1996319594C2780868878 @default.
- W1996319594 hasConceptScore W1996319594C3008058167 @default.
- W1996319594 hasConceptScore W1996319594C32611913 @default.
- W1996319594 hasConceptScore W1996319594C524204448 @default.
- W1996319594 hasConceptScore W1996319594C71924100 @default.
- W1996319594 hasConceptScore W1996319594C8891405 @default.
- W1996319594 hasConceptScore W1996319594C89623803 @default.
- W1996319594 hasIssue "8" @default.
- W1996319594 hasLocation W19963195941 @default.
- W1996319594 hasLocation W19963195942 @default.
- W1996319594 hasOpenAccess W1996319594 @default.
- W1996319594 hasPrimaryLocation W19963195941 @default.
- W1996319594 hasRelatedWork W1121313025 @default.
- W1996319594 hasRelatedWork W2019574320 @default.