Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996320306> ?p ?o ?g. }
- W1996320306 endingPage "114" @default.
- W1996320306 startingPage "97" @default.
- W1996320306 abstract "Despite their potential importance in placental HIV infection and placental immune function, nothing is known about the expression of chemokine receptors by human syncytiotrophoblast cells. Immunocytochemical analysis revealed that primary cultures of term syncytiotrophoblast cells express CCR1, CCR3, CXCR4, and CCR6. Immunohistochemical examination of cryosections of term placental villous tissue confirmed the expression of CCR3, CXCR4, and CCR6 by trophoblast cells. The primary syncytiotrophoblast cultures showed no reactivity with antibodies against CCR5. In the villous tissue sections, CCR5 was detected in stromal cells and blood vessel walls but was not found in trophoblast cells. RT-PCR analysis of RNA extracted from cultured syncytiotrophoblast cells confirmed that the cells express message for CCR1, CCR3, CXCR4, CCR6 and CCR10. No transcripts corresponding to CCR2b, CCR5, or CCR8 were detected. Other experiments showed that exposure of syncytiotrophoblast cells to soluble SDF-1alpha elicited a calcium mobilization response, consistent with the expression of functional CXCR4. Thus, human syncytiotrophoblast cells express CXCR4, a known co-receptor for TCL-tropic HIV-1 isolates but do not express CCR5, the major co-receptor for M-tropic isolates. In addition to implications for the maternal-fetal transmission of HIV, the expression of chemokine receptors by syncytiotrophoblast cells could be important in other aspects of placental immune function." @default.
- W1996320306 created "2016-06-24" @default.
- W1996320306 creator A5000351395 @default.
- W1996320306 creator A5004022276 @default.
- W1996320306 creator A5042311769 @default.
- W1996320306 creator A5082813344 @default.
- W1996320306 creator A5084143600 @default.
- W1996320306 creator A5084943724 @default.
- W1996320306 date "2001-02-01" @default.
- W1996320306 modified "2023-10-16" @default.
- W1996320306 title "Chemokine receptor expression by human syncytiotrophoblast" @default.
- W1996320306 cites W14052271 @default.
- W1996320306 cites W1523507291 @default.
- W1996320306 cites W1567337111 @default.
- W1996320306 cites W1567528464 @default.
- W1996320306 cites W1622684250 @default.
- W1996320306 cites W1774192863 @default.
- W1996320306 cites W1782049572 @default.
- W1996320306 cites W1840516913 @default.
- W1996320306 cites W1884679611 @default.
- W1996320306 cites W1965019797 @default.
- W1996320306 cites W1976573236 @default.
- W1996320306 cites W1982528951 @default.
- W1996320306 cites W2001528107 @default.
- W1996320306 cites W2003040183 @default.
- W1996320306 cites W2014896342 @default.
- W1996320306 cites W2016482852 @default.
- W1996320306 cites W2024785286 @default.
- W1996320306 cites W2027951874 @default.
- W1996320306 cites W2035695230 @default.
- W1996320306 cites W2036613215 @default.
- W1996320306 cites W2042451508 @default.
- W1996320306 cites W2046809313 @default.
- W1996320306 cites W2047336507 @default.
- W1996320306 cites W2050374486 @default.
- W1996320306 cites W2057494656 @default.
- W1996320306 cites W2059413226 @default.
- W1996320306 cites W2060294130 @default.
- W1996320306 cites W2072273657 @default.
- W1996320306 cites W2077494883 @default.
- W1996320306 cites W2083042943 @default.
- W1996320306 cites W2087343656 @default.
- W1996320306 cites W2090921383 @default.
- W1996320306 cites W2094138687 @default.
- W1996320306 cites W2100267867 @default.
- W1996320306 cites W2107679332 @default.
- W1996320306 cites W2118526748 @default.
- W1996320306 cites W2123324368 @default.
- W1996320306 cites W2124617998 @default.
- W1996320306 cites W2129059285 @default.
- W1996320306 cites W2131997843 @default.
- W1996320306 cites W2143372911 @default.
- W1996320306 cites W2147169218 @default.
- W1996320306 cites W2155117467 @default.
- W1996320306 cites W2159225279 @default.
- W1996320306 cites W2162193497 @default.
- W1996320306 cites W2167503858 @default.
- W1996320306 cites W2182858421 @default.
- W1996320306 cites W2319686405 @default.
- W1996320306 doi "https://doi.org/10.1016/s0165-0378(00)00083-8" @default.
- W1996320306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11164896" @default.
- W1996320306 hasPublicationYear "2001" @default.
- W1996320306 type Work @default.
- W1996320306 sameAs 1996320306 @default.
- W1996320306 citedByCount "33" @default.
- W1996320306 countsByYear W19963203062013 @default.
- W1996320306 countsByYear W19963203062015 @default.
- W1996320306 countsByYear W19963203062016 @default.
- W1996320306 countsByYear W19963203062020 @default.
- W1996320306 countsByYear W19963203062021 @default.
- W1996320306 countsByYear W19963203062022 @default.
- W1996320306 crossrefType "journal-article" @default.
- W1996320306 hasAuthorship W1996320306A5000351395 @default.
- W1996320306 hasAuthorship W1996320306A5004022276 @default.
- W1996320306 hasAuthorship W1996320306A5042311769 @default.
- W1996320306 hasAuthorship W1996320306A5082813344 @default.
- W1996320306 hasAuthorship W1996320306A5084143600 @default.
- W1996320306 hasAuthorship W1996320306A5084943724 @default.
- W1996320306 hasConcept C12823836 @default.
- W1996320306 hasConcept C128879288 @default.
- W1996320306 hasConcept C129013479 @default.
- W1996320306 hasConcept C13373296 @default.
- W1996320306 hasConcept C1423137 @default.
- W1996320306 hasConcept C153911025 @default.
- W1996320306 hasConcept C172680121 @default.
- W1996320306 hasConcept C203014093 @default.
- W1996320306 hasConcept C2776953305 @default.
- W1996320306 hasConcept C2777495146 @default.
- W1996320306 hasConcept C2779234561 @default.
- W1996320306 hasConcept C2779315647 @default.
- W1996320306 hasConcept C45635710 @default.
- W1996320306 hasConcept C54355233 @default.
- W1996320306 hasConcept C86803240 @default.
- W1996320306 hasConcept C8891405 @default.
- W1996320306 hasConcept C94205230 @default.
- W1996320306 hasConcept C95444343 @default.
- W1996320306 hasConceptScore W1996320306C12823836 @default.
- W1996320306 hasConceptScore W1996320306C128879288 @default.