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• W1996325724 abstract "An analysis of the binding of the 8-O-N-tert-butoxycarbonyl-12-aminododecanoyl derivative of 8-O-debutanoylthapsigargin to the target molecule, the SERCA pump, has revealed the importance of the length and flexibility of the side chain attached to O-8. Based on the analysis a series of analogues to the 2-unsubstituted analogue trilobolide has been constructed and shown to be equipotent with thapsigargin as SERCA inhibitors. Only the 12-Boc-aminododecaonoyl derivative, however, was found to be apoptotic." @default.
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• W1996325724 date "2006-04-01" @default.
• W1996325724 modified "2023-09-23" @default.
• W1996325724 title "Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells" @default.
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• W1996325724 doi "https://doi.org/10.1016/j.bmc.2005.12.001" @default.
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