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• W1996329666 abstract "—Glutamic acid decarboxylase was determined in seven brain regions: hypo-thalamus; midbrain; thalamus; corpus striatum; cerebral cortex-hippocampus; medulla-pons; and cerebellum, of suckling rats subjected to Vitamin B6 deficiency for 2 weeks from birth; of adult rats subjected to the deficiency for 5 weeks and of their respective controls. Large regional variations in the enzyme activity were found in brains of both adult and suckling control rats. The activity of the enzyme (assayed without pyridoxal phosphate) and its saturation with endogenous cofactor were markedly reduced in all brain regions of both suckling and adult pyridoxine-deficient rats. The apoenzyme (activity assayed with pyridoxal phosphate), in adult rat brain, showed no change with the deficiency in all regions except in the cerebellum where it increased slightly. In pyridoxine-deficient suckling rat brain, the apoenzyme increased substantially in all regions suggesting a process of enzyme induction. The increase in apoenzyme varied from region to region." @default.
• W1996329666 created "2016-06-24" @default.
• W1996329666 creator A5005184745 @default.
• W1996329666 creator A5082169436 @default.
• W1996329666 date "1973-09-01" @default.
• W1996329666 modified "2023-09-24" @default.
• W1996329666 title "REGIONAL DISTRIBUTION OF GLUTAMIC ACID DECARBOXYLASE IN THE DEVELOPING BRAIN OF THE PYRIDOXINE-DEFICIENT RAT" @default.
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• W1996329666 doi "https://doi.org/10.1111/j.1471-4159.1973.tb06005.x" @default.
• W1996329666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4742140" @default.
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