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- W1996348712 endingPage "53" @default.
- W1996348712 startingPage "41" @default.
- W1996348712 abstract "The exploitation of preparations of Cannabis sativa to combat pain seems to date back to time immemorial, although their psychotropic effects, which are at the bases of their recreational use and limit their therapeutic use, are at least as ancient. Indeed, it has always been different to tease apart the unwanted central effects from the therapeutic benefits of Δ9-tetrahydrocannabinol (THC), the main psychotropic component of cannabis. The discovery of the cannabinoid receptors and of their endogenous ligands, the endocannabinoids, which, unlike THC, play a pro-homeostatic function in a tissue- and time-selective manner, offered the opportunity to develop new analgesics from synthetic inhibitors of endocannabinoid inactivation. The advantages of this approach over direct activation of cannabinoid receptors as a therapeutic strategy against neuropathic and inflammatory pain are discussed here along with its potential complications. These latter have been such that clinical success has been achieved so far more rapidly with naturally occurring THC or endocannabinoid structural analogues acting at a plethora of cannabinoid-related and -unrelated molecular targets, than with selective inhibitors of endocannabinoid enzymatic hydrolysis, thus leading to revisit the potential usefulness of “multi-target” versus “magic bullet” compounds as new analgesics." @default.
- W1996348712 created "2016-06-24" @default.
- W1996348712 creator A5007484138 @default.
- W1996348712 creator A5054954393 @default.
- W1996348712 date "2013-09-01" @default.
- W1996348712 modified "2023-09-30" @default.
- W1996348712 title "Non-psychotropic analgesic drugs from the endocannabinoid system: “Magic bullet” or “multiple-target” strategies?" @default.
- W1996348712 cites W1482026204 @default.
- W1996348712 cites W1488329806 @default.
- W1996348712 cites W1500005891 @default.
- W1996348712 cites W1500927173 @default.
- W1996348712 cites W1505609996 @default.
- W1996348712 cites W1539660754 @default.
- W1996348712 cites W1568755291 @default.
- W1996348712 cites W1572519545 @default.
- W1996348712 cites W1593785499 @default.
- W1996348712 cites W1744763481 @default.
- W1996348712 cites W1746022025 @default.
- W1996348712 cites W1907919347 @default.
- W1996348712 cites W1927188913 @default.
- W1996348712 cites W1963753398 @default.
- W1996348712 cites W1966150192 @default.
- W1996348712 cites W1967303451 @default.
- W1996348712 cites W1969338731 @default.
- W1996348712 cites W1970618996 @default.
- W1996348712 cites W1978798118 @default.
- W1996348712 cites W1980028866 @default.
- W1996348712 cites W1982429227 @default.
- W1996348712 cites W1987479668 @default.
- W1996348712 cites W1987613482 @default.
- W1996348712 cites W1988795372 @default.
- W1996348712 cites W1989073099 @default.
- W1996348712 cites W1989737013 @default.
- W1996348712 cites W1991349787 @default.
- W1996348712 cites W1994127033 @default.
- W1996348712 cites W1996081689 @default.
- W1996348712 cites W1997513305 @default.
- W1996348712 cites W1997879052 @default.
- W1996348712 cites W1998106503 @default.
- W1996348712 cites W1998532089 @default.
- W1996348712 cites W1999646805 @default.
- W1996348712 cites W2000660857 @default.
- W1996348712 cites W2002797425 @default.
- W1996348712 cites W2004071649 @default.
- W1996348712 cites W2004848791 @default.
- W1996348712 cites W2006401652 @default.
- W1996348712 cites W2006503897 @default.
- W1996348712 cites W2007780291 @default.
- W1996348712 cites W2008749179 @default.
- W1996348712 cites W2015080435 @default.
- W1996348712 cites W2016925095 @default.
- W1996348712 cites W2018479387 @default.
- W1996348712 cites W2018797949 @default.
- W1996348712 cites W2023718219 @default.
- W1996348712 cites W2024009202 @default.
- W1996348712 cites W2024653583 @default.
- W1996348712 cites W2025862718 @default.
- W1996348712 cites W2027176103 @default.
- W1996348712 cites W2029778830 @default.
- W1996348712 cites W2030623240 @default.
- W1996348712 cites W2030777873 @default.
- W1996348712 cites W2031071131 @default.
- W1996348712 cites W2033605840 @default.
- W1996348712 cites W2034885654 @default.
- W1996348712 cites W2037219926 @default.
- W1996348712 cites W2037393750 @default.
- W1996348712 cites W2039772414 @default.
- W1996348712 cites W2040059186 @default.
- W1996348712 cites W2041544574 @default.
- W1996348712 cites W2043033522 @default.
- W1996348712 cites W2045592577 @default.
- W1996348712 cites W2050320031 @default.
- W1996348712 cites W2050346904 @default.
- W1996348712 cites W2051554315 @default.
- W1996348712 cites W2053495851 @default.
- W1996348712 cites W2056188558 @default.
- W1996348712 cites W2056696760 @default.
- W1996348712 cites W2059154612 @default.
- W1996348712 cites W2061301719 @default.
- W1996348712 cites W2063013053 @default.
- W1996348712 cites W2064701388 @default.
- W1996348712 cites W2066159223 @default.
- W1996348712 cites W2067924690 @default.
- W1996348712 cites W2067960394 @default.
- W1996348712 cites W2068903408 @default.
- W1996348712 cites W2069590129 @default.
- W1996348712 cites W2070876717 @default.
- W1996348712 cites W2071186158 @default.
- W1996348712 cites W2072880786 @default.
- W1996348712 cites W2075072943 @default.
- W1996348712 cites W2075894678 @default.
- W1996348712 cites W2076195364 @default.
- W1996348712 cites W2077059461 @default.
- W1996348712 cites W2078196652 @default.
- W1996348712 cites W2083155364 @default.
- W1996348712 cites W2084283702 @default.
- W1996348712 cites W2085852831 @default.
- W1996348712 cites W2092971703 @default.