FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996352992> ?p ?o ?g. }

• W1996352992 endingPage "8" @default.
• W1996352992 startingPage "3" @default.
• W1996352992 abstract "A reliable medium-term bioassay system for rapid detection of carcinogenic potential of chemicals in the human environment has been developed. The 8-week-protocol consists of 2 stages; male F344 rats are given a single intraperitoneal injection of diethylnitrosamine (200 mg/kg) for initiation of liver carcinogenesis, followed by a 6-week test chemical treatment starting 2 weeks thereafter. Test chemicals are usually given in the diet or the drinking water and in the 2nd week of test chemical treatment, all rats are subjected to two-thirds partial hepatectomy in order to induce regenerative cell replication. The end-point marker is the glutathione S-transferase placental form (GST-P)-positive hepatic focus, the numbers and sizes of which are analyzed using an image-analyzer and expressed as values per unit liver section (1 cm2). When the yield of GST-P-positive foci is significantly enhanced (P<0.05) over the control value, a chemical is judged to possess carcinogenic or promotion potential for the liver. Among 313 chemicals already tested in this system in our laboratory, 30/31 (97%) mutagenic hepatocarcinogens and 29/33 (88%) non-mutagenic hepatocarcinogens gave positive results. Ten out of 43 (23%) agents known to be carcinogenic in organs other than the liver were also positive. It is particularly important that only one of 48 non-carcinogens gave a very weak positive result, so that the system has a very low false-positivity rate. It is now well documented that the assay system is highly effective for detecting hepatocarcinogens, bridging the gap between traditional long-term carcinogenicity tests and short-term screening assays. At the Fourth International Conference on Harmonization, our medium-term liver bioassay based on an initiation and promotion protocol was recommended in the guidelines as an acceptable alternative to the long-term rodent carcinogenicity test. (Cancer Sci 2003; 94: 3–8)" @default.
• W1996352992 created "2016-06-24" @default.
• W1996352992 creator A5004431119 @default.
• W1996352992 creator A5016135291 @default.
• W1996352992 creator A5054388953 @default.
• W1996352992 date "2003-01-01" @default.
• W1996352992 modified "2023-10-12" @default.
• W1996352992 title "A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals" @default.
• W1996352992 cites W1966220682 @default.
• W1996352992 cites W1969413160 @default.
• W1996352992 cites W1972987236 @default.
• W1996352992 cites W1975863272 @default.
• W1996352992 cites W1983043038 @default.
• W1996352992 cites W1996278133 @default.
• W1996352992 cites W1996363343 @default.
• W1996352992 cites W2014007215 @default.
• W1996352992 cites W2020445182 @default.
• W1996352992 cites W2026156327 @default.
• W1996352992 cites W2034715475 @default.
• W1996352992 cites W2046596584 @default.
• W1996352992 cites W2049322536 @default.
• W1996352992 cites W2056785620 @default.
• W1996352992 cites W2065107673 @default.
• W1996352992 cites W2070256254 @default.
• W1996352992 cites W2077966828 @default.
• W1996352992 cites W2087043528 @default.
• W1996352992 cites W2087617868 @default.
• W1996352992 cites W2118633304 @default.
• W1996352992 cites W2123790853 @default.
• W1996352992 cites W2125671308 @default.
• W1996352992 cites W2128111772 @default.
• W1996352992 cites W2146366253 @default.
• W1996352992 cites W2147874361 @default.
• W1996352992 cites W2312977193 @default.
• W1996352992 doi "https://doi.org/10.1111/j.1349-7006.2003.tb01343.x" @default.
• W1996352992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12708466" @default.
• W1996352992 hasPublicationYear "2003" @default.
• W1996352992 type Work @default.
• W1996352992 sameAs 1996352992 @default.
• W1996352992 citedByCount "153" @default.
• W1996352992 countsByYear W19963529922012 @default.
• W1996352992 countsByYear W19963529922013 @default.
• W1996352992 countsByYear W19963529922014 @default.
• W1996352992 countsByYear W19963529922015 @default.
• W1996352992 countsByYear W19963529922016 @default.
• W1996352992 countsByYear W19963529922017 @default.
• W1996352992 countsByYear W19963529922018 @default.
• W1996352992 countsByYear W19963529922019 @default.
• W1996352992 countsByYear W19963529922020 @default.
• W1996352992 countsByYear W19963529922021 @default.
• W1996352992 countsByYear W19963529922022 @default.
• W1996352992 countsByYear W19963529922023 @default.
• W1996352992 crossrefType "journal-article" @default.
• W1996352992 hasAuthorship W1996352992A5004431119 @default.
• W1996352992 hasAuthorship W1996352992A5016135291 @default.
• W1996352992 hasAuthorship W1996352992A5054388953 @default.
• W1996352992 hasBestOaLocation W19963529921 @default.
• W1996352992 hasConcept C104488531 @default.
• W1996352992 hasConcept C114246631 @default.
• W1996352992 hasConcept C121608353 @default.
• W1996352992 hasConcept C126322002 @default.
• W1996352992 hasConcept C142724271 @default.
• W1996352992 hasConcept C181199279 @default.
• W1996352992 hasConcept C185592680 @default.
• W1996352992 hasConcept C207001950 @default.
• W1996352992 hasConcept C2780159080 @default.
• W1996352992 hasConcept C29730261 @default.
• W1996352992 hasConcept C33070731 @default.
• W1996352992 hasConcept C42407357 @default.
• W1996352992 hasConcept C538909803 @default.
• W1996352992 hasConcept C54355233 @default.
• W1996352992 hasConcept C55493867 @default.
• W1996352992 hasConcept C555283112 @default.
• W1996352992 hasConcept C71924100 @default.
• W1996352992 hasConcept C86803240 @default.
• W1996352992 hasConcept C98274493 @default.
• W1996352992 hasConceptScore W1996352992C104488531 @default.
• W1996352992 hasConceptScore W1996352992C114246631 @default.
• W1996352992 hasConceptScore W1996352992C121608353 @default.
• W1996352992 hasConceptScore W1996352992C126322002 @default.
• W1996352992 hasConceptScore W1996352992C142724271 @default.
• W1996352992 hasConceptScore W1996352992C181199279 @default.
• W1996352992 hasConceptScore W1996352992C185592680 @default.
• W1996352992 hasConceptScore W1996352992C207001950 @default.
• W1996352992 hasConceptScore W1996352992C2780159080 @default.
• W1996352992 hasConceptScore W1996352992C29730261 @default.
• W1996352992 hasConceptScore W1996352992C33070731 @default.
• W1996352992 hasConceptScore W1996352992C42407357 @default.
• W1996352992 hasConceptScore W1996352992C538909803 @default.
• W1996352992 hasConceptScore W1996352992C54355233 @default.
• W1996352992 hasConceptScore W1996352992C55493867 @default.
• W1996352992 hasConceptScore W1996352992C555283112 @default.
• W1996352992 hasConceptScore W1996352992C71924100 @default.
• W1996352992 hasConceptScore W1996352992C86803240 @default.
• W1996352992 hasConceptScore W1996352992C98274493 @default.
• W1996352992 hasIssue "1" @default.
• W1996352992 hasLocation W19963529921 @default.
• W1996352992 hasLocation W19963529922 @default.

• next