FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996370147> ?p ?o ?g. }

• W1996370147 endingPage "200" @default.
• W1996370147 startingPage "187" @default.
• W1996370147 abstract "Mounting experimental evidence has suggested that the trophic environment of cells in culture is an important determinant of their vulnerability to the cytotoxic effects of reactive oxidants such as peroxynitrite (ONOO(-)). However, acidic fibroblast growth factor (FGF-1)-induced signaling renders some cells more sensitive and others resistant to the cytotoxic effects of ONOO(-). To determine whether alternatively spliced fibroblast growth factor receptor (FGFR-1) isoforms are responsible for this differential response, we have stably transfected FGFR-negative rat brain-derived resistant vessel endothelial cells (RVEC) with human cDNA sequences encoding either FGFR-1 alpha or FGFR-1 beta. FGF-1 treatment of RVEC(R-1 alpha) transfectants enhanced ONOO(-)-mediated cell death in a manner dependent upon FGFR-1 tyrosine kinase, MEK/Erk 1/2 kinase, and p38 MAP kinase activities and independent of Src-family kinase (SFK) activity. FGF-1 treatment of RVEC(R-1 beta) transfectants inhibited the cytotoxic effects of ONOO(-) in a manner dependent upon FGFR-1 tyrosine kinase, MEK/Erk 1/2 kinase, and SFK activities and independent of p38 MAP kinase activity. FGF-1-induced preactivation of both FGFR-1 tyrosine and Erk 1/2 kinases was detected in both RVEC(R-1 alpha) and RVEC(R-1 beta) transfectants. FGF-1-induced preactivation of p38 MAPK was restricted to RVEC(R-1 alpha) transfectants, whereas, ligand-induced preactivation of SFK was limited to RVEC(R-1 beta) transfectants. Collectively, these results both reemphasize the role of extracellular trophic factors and their receptor-mediated signaling pathways during cellular responses to oxidant stress and provide a first indication that the alternatively spliced FGFR-1 isoforms induce differential signal transduction pathways." @default.
• W1996370147 created "2016-06-24" @default.
• W1996370147 creator A5002327164 @default.
• W1996370147 creator A5018091007 @default.
• W1996370147 creator A5040167645 @default.
• W1996370147 creator A5059284121 @default.
• W1996370147 creator A5060842906 @default.
• W1996370147 creator A5067238310 @default.
• W1996370147 date "2003-02-01" @default.
• W1996370147 modified "2023-09-28" @default.
• W1996370147 title "Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite" @default.
• W1996370147 cites W1490194809 @default.
• W1996370147 cites W1495804697 @default.
• W1996370147 cites W1500094754 @default.
• W1996370147 cites W1505685265 @default.
• W1996370147 cites W1509127316 @default.
• W1996370147 cites W1513451331 @default.
• W1996370147 cites W1588963749 @default.
• W1996370147 cites W1592656278 @default.
• W1996370147 cites W1598196431 @default.
• W1996370147 cites W1821918060 @default.
• W1996370147 cites W1863695472 @default.
• W1996370147 cites W1957742134 @default.
• W1996370147 cites W1963891523 @default.
• W1996370147 cites W1978038466 @default.
• W1996370147 cites W1983236757 @default.
• W1996370147 cites W1984890353 @default.
• W1996370147 cites W1987758728 @default.
• W1996370147 cites W1988202910 @default.
• W1996370147 cites W1991957995 @default.
• W1996370147 cites W1999589434 @default.
• W1996370147 cites W1999882817 @default.
• W1996370147 cites W2001099356 @default.
• W1996370147 cites W2003632139 @default.
• W1996370147 cites W2010424252 @default.
• W1996370147 cites W2022377100 @default.
• W1996370147 cites W2030140856 @default.
• W1996370147 cites W2033019269 @default.
• W1996370147 cites W2034090422 @default.
• W1996370147 cites W2035632074 @default.
• W1996370147 cites W2036291368 @default.
• W1996370147 cites W2038843757 @default.
• W1996370147 cites W2039626545 @default.
• W1996370147 cites W2043813981 @default.
• W1996370147 cites W2045465249 @default.
• W1996370147 cites W2045840768 @default.
• W1996370147 cites W2045844654 @default.
• W1996370147 cites W2049170487 @default.
• W1996370147 cites W2051158094 @default.
• W1996370147 cites W2051442934 @default.
• W1996370147 cites W2051453216 @default.
• W1996370147 cites W2061481569 @default.
• W1996370147 cites W2064472395 @default.
• W1996370147 cites W2072303535 @default.
• W1996370147 cites W2076133689 @default.
• W1996370147 cites W2082198112 @default.
• W1996370147 cites W2085935168 @default.
• W1996370147 cites W2086919008 @default.
• W1996370147 cites W2087614633 @default.
• W1996370147 cites W2090025491 @default.
• W1996370147 cites W2090316954 @default.
• W1996370147 cites W2090895449 @default.
• W1996370147 cites W2093708814 @default.
• W1996370147 cites W2120620942 @default.
• W1996370147 cites W2120652037 @default.
• W1996370147 cites W2122892477 @default.
• W1996370147 cites W2123788692 @default.
• W1996370147 cites W2129953156 @default.
• W1996370147 cites W2138178479 @default.
• W1996370147 cites W2138431969 @default.
• W1996370147 cites W2152746956 @default.
• W1996370147 cites W2170351820 @default.
• W1996370147 cites W2200373941 @default.
• W1996370147 cites W2228279685 @default.
• W1996370147 cites W2313518958 @default.
• W1996370147 cites W2316918019 @default.
• W1996370147 cites W2327615593 @default.
• W1996370147 cites W2328367416 @default.
• W1996370147 cites W2332029728 @default.
• W1996370147 cites W4250626408 @default.
• W1996370147 cites W4251112183 @default.
• W1996370147 doi "https://doi.org/10.1016/s0003-9861(02)00681-1" @default.
• W1996370147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12573278" @default.
• W1996370147 hasPublicationYear "2003" @default.
• W1996370147 type Work @default.
• W1996370147 sameAs 1996370147 @default.
• W1996370147 citedByCount "10" @default.
• W1996370147 countsByYear W19963701472013 @default.
• W1996370147 countsByYear W19963701472014 @default.
• W1996370147 countsByYear W19963701472017 @default.
• W1996370147 countsByYear W19963701472019 @default.
• W1996370147 crossrefType "journal-article" @default.
• W1996370147 hasAuthorship W1996370147A5002327164 @default.
• W1996370147 hasAuthorship W1996370147A5018091007 @default.
• W1996370147 hasAuthorship W1996370147A5040167645 @default.
• W1996370147 hasAuthorship W1996370147A5059284121 @default.
• W1996370147 hasAuthorship W1996370147A5060842906 @default.
• W1996370147 hasAuthorship W1996370147A5067238310 @default.

• next