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• W1996376265 abstract "The effects of (+)-β-d-dioxolane-cytosine ((+)-d-β-DOC), (−)-β-l-dioxolane-cytosine ((−)-l-β-DOC), (+)-β-d-oxathiolane-cytosine ((+)-d-β-OTC), (−)-β-l-oxathiolane-cytosine ((−)-l-β-OTC, or 3TC), 3′-azido-2′,3′-dideoxy-5-methyl-cytidine (5-Me-AZDC), and 3′-azido-2′,3′-dideoxyuridine (AZDU) on Epstein-Barr virus (EBV) DNA replication in vitro were tested in P3HR-1 cells. Two anti-EBV drugs, 3′-azido-3′-deoxythymidine (AZT) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG, or ganciclovir), were used as positive controls. The inhibitory effects on EBV DNA synthesis were quantified by membrane filter and Southern blot hybridizations with an EBV-specific probe BamHI-W fragment. The 50% effective doses (ED50) for EBV DNA replication were 0.15, 0.83, 1.5, 8.3, 14, and 7.7 μM for DHPG, (−)-l-β-DOC, (+)-d-β-DOC, (+)-d-β-OTC, (−)-l-β-OTC, and AZT, respectively. In contrast, 5-Me-AZDC and AZDU were not effective at concentrations as high as 30 μM. These results indicated that both (−)-l-β-DOC and (+)-d-β-DOC were more potent than AZT, which has previously been shown to have anti-EBV activity. (−)-l-β-DOC and (+)-d-β-DOC have also been previously demonstrated to suppress the infectivity of human immunodeficiency virus type 1 (HIV-1). Thus, (−)-l-β-DOC represents the first nucleoside analog with l-configuration exhibiting significant antiviral activities against both EBV and HIV." @default.
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• W1996376265 date "1995-09-01" @default.
• W1996376265 modified "2023-09-23" @default.
• W1996376265 title "Some nucleoside analogs with anti-human immunodeficiency virus activity inhibit replication of Epstein-Barr virus" @default.
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• W1996376265 doi "https://doi.org/10.1016/0166-3542(95)92835-b" @default.
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