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- W1996385306 abstract "Maintenance of genomic integrity is one of the fundamental biological properties shared by all living organisms. To counterbalance deleterious and potentially mutagenic effects of omnipresent DNA damaging assaults, organisms have developed a network of genome surveillance and maintenance pathways known as the DNA damage response. In eukaryotes, the orchestration of cell-cycle checkpoints, DNA damage repair, and apoptosis in response to DNA damage relies on posttranslational modifications of key regulatory proteins. Although the role of phosphorylation in these pathways is relatively well established, the significance of ubiquitylation has only recently emerged. In this review, we survey current research on the ubiquitin-proteasome system, focusing on the DNA damage response in the G2 phase of the cell cycle and two prominent classes of ubiquitin ligases, the SCF- and APC/C complexes. These ubiquitin ligases are reviewed with regard to their function in activating, maintaining, and terminating the checkpoint and in light of increasing evidence that suggests a dynamic balance of substrate ubiquitylation and deubiquitylation. We further discuss the impact of defective G2 checkpoint signaling on genomic stability and cancer risk, highlighting strategies for targeted antitumor drug discovery." @default.
- W1996385306 created "2016-06-24" @default.
- W1996385306 creator A5034919044 @default.
- W1996385306 creator A5059538708 @default.
- W1996385306 date "2009-08-14" @default.
- W1996385306 modified "2023-10-16" @default.
- W1996385306 title "Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2" @default.
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- W1996385306 doi "https://doi.org/10.1038/cdd.2009.104" @default.
- W1996385306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19680264" @default.
- W1996385306 hasPublicationYear "2009" @default.
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